MET25_MOUSE
ID MET25_MOUSE Reviewed; 597 AA.
AC Q6NXH8; Q3UMX5;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Probable methyltransferase-like protein 25 {ECO:0000305};
DE EC=2.1.1.- {ECO:0000305};
GN Name=Mettl25;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable methyltransferase. {ECO:0000305}.
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DR EMBL; AK144620; BAE25973.1; -; mRNA.
DR EMBL; BC067068; AAH67068.1; -; mRNA.
DR RefSeq; NP_997405.2; NM_207522.2.
DR AlphaFoldDB; Q6NXH8; -.
DR STRING; 10090.ENSMUSP00000038665; -.
DR iPTMnet; Q6NXH8; -.
DR PhosphoSitePlus; Q6NXH8; -.
DR EPD; Q6NXH8; -.
DR PaxDb; Q6NXH8; -.
DR PRIDE; Q6NXH8; -.
DR ProteomicsDB; 292297; -.
DR GeneID; 216292; -.
DR KEGG; mmu:216292; -.
DR UCSC; uc007gyo.2; mouse.
DR CTD; 84190; -.
DR MGI; MGI:3041259; Mettl25.
DR eggNOG; KOG2651; Eukaryota.
DR InParanoid; Q6NXH8; -.
DR OrthoDB; 1014832at2759; -.
DR PhylomeDB; Q6NXH8; -.
DR TreeFam; TF312998; -.
DR BioGRID-ORCS; 216292; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q6NXH8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6NXH8; protein.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF13679; Methyltransf_32; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Reference proteome; Transferase.
FT CHAIN 1..597
FT /note="Probable methyltransferase-like protein 25"
FT /id="PRO_0000252149"
FT REGION 245..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1
FT /note="M -> MSVM (in Ref. 1; BAE25973)"
FT /evidence="ECO:0000305"
FT CONFLICT 596
FT /note="L -> R (in Ref. 1; BAE25973)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 597 AA; 66736 MW; 7A9EA68D75217F1F CRC64;
MAAACPLPRT PDLPTLHDKL QGLLSFLRGA LAISSAHTVD FYTKSVWQEL VDLPPESVLA
ALRESAVEAE PREAETGSGF TELPKIFCET SQKLLSVEAF ARTAKHYSVQ NLGLCTPSEQ
LLTALQGNKR QRVDENVKAI EFMNTKKSHE VQAMSELICS IADYCGLKQI IDVGSGKGYL
SSFLSLKYGL NVYGIDSSNT NTHGAKERNR KLKKHWSLYH PHSRADANGW ASERPRELKV
PKGVECKGDA ESVQRSRLGN PDLSATDGLP DFSGSAISVI RKQQKNVLAQ PAEEENLYFE
DAFSLIDFLP VDAIEPTSSQ VQNTEKSGLR KERRNTASKA RDSSIYSPLT SFITADSQLH
DIIEDLEDCL MVGLHTCGDL APSTLRIFTS KAEVKAVCSV GCCYHLLSEE FENQHKDRCA
NENWGFPMCH YLKEERWCCG RNARMSACLA LQRVAVGQGL PTESLFYRAV LQNIIKDYYG
ISKCEQHVGK IYSKCSSFLE YVRMSLKKLG LDESKVSEEI IMDYYENYKP RMNELEAFNM
LKVVLAPCIE TLILLDRLCY LKEQDGVAWS ALVKLFDPVQ SPRCYAVIAL KKQCDLG
