ARL10_HUMAN
ID ARL10_HUMAN Reviewed; 244 AA.
AC Q8N8L6;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=ADP-ribosylation factor-like protein 10;
GN Name=ARL10; Synonyms=ARL10A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP IDENTIFICATION.
RX PubMed=15033445; DOI=10.1016/j.bbrc.2004.02.091;
RA Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M.,
RA Verjovski-Almeida S., Reis E.M.;
RT "Rasl11a, member of a novel small monomeric GTPase gene family, is
RT differentially expressed in prostate tumors.";
RL Biochem. Biophys. Res. Commun. 316:618-627(2004).
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; AK096568; BAC04820.1; -; mRNA.
DR EMBL; BK001673; DAA02136.1; -; mRNA.
DR CCDS; CCDS4400.1; -.
DR RefSeq; NP_775935.1; NM_173664.5.
DR AlphaFoldDB; Q8N8L6; -.
DR SMR; Q8N8L6; -.
DR BioGRID; 130153; 46.
DR IntAct; Q8N8L6; 24.
DR STRING; 9606.ENSP00000308496; -.
DR iPTMnet; Q8N8L6; -.
DR PhosphoSitePlus; Q8N8L6; -.
DR BioMuta; ARL10; -.
DR DMDM; 74751109; -.
DR EPD; Q8N8L6; -.
DR jPOST; Q8N8L6; -.
DR MassIVE; Q8N8L6; -.
DR PaxDb; Q8N8L6; -.
DR PeptideAtlas; Q8N8L6; -.
DR PRIDE; Q8N8L6; -.
DR ProteomicsDB; 72435; -.
DR Antibodypedia; 29070; 80 antibodies from 16 providers.
DR DNASU; 285598; -.
DR Ensembl; ENST00000310389.6; ENSP00000308496.5; ENSG00000175414.7.
DR GeneID; 285598; -.
DR KEGG; hsa:285598; -.
DR MANE-Select; ENST00000310389.6; ENSP00000308496.5; NM_173664.6; NP_775935.1.
DR UCSC; uc003mec.2; human.
DR CTD; 285598; -.
DR GeneCards; ARL10; -.
DR HGNC; HGNC:22042; ARL10.
DR HPA; ENSG00000175414; Low tissue specificity.
DR neXtProt; NX_Q8N8L6; -.
DR OpenTargets; ENSG00000175414; -.
DR PharmGKB; PA134871031; -.
DR VEuPathDB; HostDB:ENSG00000175414; -.
DR eggNOG; KOG0072; Eukaryota.
DR GeneTree; ENSGT00940000160017; -.
DR HOGENOM; CLU_040729_11_0_1; -.
DR InParanoid; Q8N8L6; -.
DR OMA; QAAYCTI; -.
DR OrthoDB; 1410051at2759; -.
DR PhylomeDB; Q8N8L6; -.
DR TreeFam; TF105469; -.
DR PathwayCommons; Q8N8L6; -.
DR SignaLink; Q8N8L6; -.
DR BioGRID-ORCS; 285598; 25 hits in 1063 CRISPR screens.
DR ChiTaRS; ARL10; human.
DR GenomeRNAi; 285598; -.
DR Pharos; Q8N8L6; Tdark.
DR PRO; PR:Q8N8L6; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8N8L6; protein.
DR Bgee; ENSG00000175414; Expressed in Brodmann (1909) area 23 and 169 other tissues.
DR ExpressionAtlas; Q8N8L6; baseline and differential.
DR Genevisible; Q8N8L6; HS.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR042951; ARL10.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR47575; PTHR47575; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..244
FT /note="ADP-ribosylation factor-like protein 10"
FT /id="PRO_0000207476"
FT BINDING 84..91
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 128..132
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 185..188
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 244 AA; 27459 MW; 56F2DFEA9AA51C9D CRC64;
MAPRPLGPLV LALGGAAAVL GSVLFILWKT YFGRGRERRW DRGEAWWGAE AARLPEWDEW
DPEDEEDEEP ALEELEQREV LVLGLDGAGK STFLRVLSGK PPLEGHIPTW GFNSVRLPTK
DFEVDLLEIG GSQNLRFYWK EFVSEVDVLV FVVDSADRLR LPWARQELHK LLDKDPDLPV
VVVANKQDLS EAMSMGELQR ELGLQAIDNQ REVFLLAASI APAGPTFEEP GTVHIWKLLL
ELLS
