ARL11_HUMAN
ID ARL11_HUMAN Reviewed; 196 AA.
AC Q969Q4;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=ADP-ribosylation factor-like protein 11;
DE AltName: Full=ADP-ribosylation factor-like tumor suppressor protein 1;
GN Name=ARL11; Synonyms=ARLTS1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE, VARIANTS LEU-22;
RP LEU-131; ARG-148 AND LYS-164, AND FUNCTION.
RC TISSUE=Bone marrow, and Spleen;
RX PubMed=15843669; DOI=10.1056/nejmoa042280;
RA Calin G.A., Trapasso F., Shimizu M., Dumitru C.D., Yendamuri S.,
RA Godwin A.K., Ferracin M., Bernardi G., Chatterjee D., Baldassarre G.,
RA Rattan S., Alder H., Mabuchi H., Shiraishi T., Hansen L.L., Overgaard J.,
RA Herlea V., Mauro F.R., Dighiero G., Movsas B., Rassenti L., Kipps T.,
RA Baffa R., Fusco A., Mori M., Russo G., Liu C.-G., Neuberg D., Bullrich F.,
RA Negrini M., Croce C.M.;
RT "Familial cancer associated with a polymorphism in ARLTS1.";
RL N. Engl. J. Med. 352:1667-1676(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in apoptosis. May act as a tumor suppressor.
CC {ECO:0000269|PubMed:15843669}.
CC -!- INTERACTION:
CC Q969Q4; Q15645: TRIP13; NbExp=4; IntAct=EBI-751892, EBI-358993;
CC -!- TISSUE SPECIFICITY: Expressed in lung and leukocytes.
CC {ECO:0000269|PubMed:15843669}.
CC -!- DISEASE: Leukemia, chronic lymphocytic (CLL) [MIM:151400]: A chronic
CC leukemia in which functionally incompetent B-lymphocytes progressively
CC accumulate in the bone marrow, blood, and lymphoid tissues. The
CC clinical evolution of the disorder is heterogeneous, with some patients
CC having indolent disease and others having aggressive disease and short
CC survival. Note=Disease susceptibility is associated with variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; AF441378; AAP19650.1; -; mRNA.
DR EMBL; AK091249; BAC03621.1; -; mRNA.
DR EMBL; AL135901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013150; AAH13150.1; -; mRNA.
DR CCDS; CCDS9419.1; -.
DR RefSeq; NP_612459.1; NM_138450.5.
DR RefSeq; XP_005266310.1; XM_005266253.3.
DR AlphaFoldDB; Q969Q4; -.
DR SMR; Q969Q4; -.
DR BioGRID; 125454; 17.
DR IntAct; Q969Q4; 7.
DR STRING; 9606.ENSP00000282026; -.
DR iPTMnet; Q969Q4; -.
DR PhosphoSitePlus; Q969Q4; -.
DR BioMuta; ARL11; -.
DR DMDM; 74751726; -.
DR EPD; Q969Q4; -.
DR jPOST; Q969Q4; -.
DR MassIVE; Q969Q4; -.
DR PaxDb; Q969Q4; -.
DR PeptideAtlas; Q969Q4; -.
DR PRIDE; Q969Q4; -.
DR ProteomicsDB; 75815; -.
DR Antibodypedia; 23950; 212 antibodies from 25 providers.
DR DNASU; 115761; -.
DR Ensembl; ENST00000282026.2; ENSP00000282026.1; ENSG00000152213.4.
DR GeneID; 115761; -.
DR KEGG; hsa:115761; -.
DR MANE-Select; ENST00000282026.2; ENSP00000282026.1; NM_138450.6; NP_612459.1.
DR UCSC; uc001vdf.2; human.
DR CTD; 115761; -.
DR DisGeNET; 115761; -.
DR GeneCards; ARL11; -.
DR HGNC; HGNC:24046; ARL11.
DR HPA; ENSG00000152213; Tissue enhanced (lymphoid).
DR MalaCards; ARL11; -.
DR MIM; 151400; phenotype.
DR MIM; 609351; gene.
DR neXtProt; NX_Q969Q4; -.
DR OpenTargets; ENSG00000152213; -.
DR Orphanet; 67038; B-cell chronic lymphocytic leukemia.
DR PharmGKB; PA134974627; -.
DR VEuPathDB; HostDB:ENSG00000152213; -.
DR eggNOG; KOG0070; Eukaryota.
DR GeneTree; ENSGT00940000162731; -.
DR HOGENOM; CLU_040729_9_2_1; -.
DR InParanoid; Q969Q4; -.
DR OMA; WRKRDAR; -.
DR OrthoDB; 1271528at2759; -.
DR PhylomeDB; Q969Q4; -.
DR TreeFam; TF105471; -.
DR PathwayCommons; Q969Q4; -.
DR SignaLink; Q969Q4; -.
DR BioGRID-ORCS; 115761; 23 hits in 1071 CRISPR screens.
DR ChiTaRS; ARL11; human.
DR GeneWiki; ARL11; -.
DR GenomeRNAi; 115761; -.
DR Pharos; Q969Q4; Tbio.
DR PRO; PR:Q969Q4; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q969Q4; protein.
DR Bgee; ENSG00000152213; Expressed in monocyte and 113 other tissues.
DR Genevisible; Q969Q4; HS.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Lipoprotein; Myristate; Nucleotide-binding;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..196
FT /note="ADP-ribosylation factor-like protein 11"
FT /id="PRO_0000207479"
FT BINDING 19..26
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 63..67
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 122..125
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT VARIANT 22
FT /note="S -> L (in dbSNP:rs147389782)"
FT /evidence="ECO:0000269|PubMed:15843669"
FT /id="VAR_023742"
FT VARIANT 120
FT /note="L -> M (in dbSNP:rs35712316)"
FT /id="VAR_048318"
FT VARIANT 131
FT /note="P -> L (in dbSNP:rs147120792)"
FT /evidence="ECO:0000269|PubMed:15843669"
FT /id="VAR_023743"
FT VARIANT 148
FT /note="C -> R (in dbSNP:rs3803185)"
FT /evidence="ECO:0000269|PubMed:15843669"
FT /id="VAR_023744"
FT VARIANT 164
FT /note="E -> K (in dbSNP:rs146850453)"
FT /evidence="ECO:0000269|PubMed:15843669"
FT /id="VAR_023745"
SQ SEQUENCE 196 AA; 21391 MW; 99389B2A2389149E CRC64;
MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT
LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL
ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC
LQARAHGAER GDSKRS
