ID   ARL11_RAT               Reviewed;         173 AA.
AC   Q5BK71;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=ADP-ribosylation factor-like protein 11;
GN   Name=Arl11;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in apoptosis. May act as a tumor suppressor
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; BC091183; AAH91183.1; -; mRNA.
DR   RefSeq; NP_001013451.1; NM_001013433.1.
DR   RefSeq; XP_006252197.1; XM_006252135.3.
DR   RefSeq; XP_017455251.1; XM_017599762.1.
DR   AlphaFoldDB; Q5BK71; -.
DR   SMR; Q5BK71; -.
DR   STRING; 10116.ENSRNOP00000019646; -.
DR   iPTMnet; Q5BK71; -.
DR   PhosphoSitePlus; Q5BK71; -.
DR   PaxDb; Q5BK71; -.
DR   PRIDE; Q5BK71; -.
DR   Ensembl; ENSRNOT00000019646; ENSRNOP00000019646; ENSRNOG00000014653.
DR   Ensembl; ENSRNOT00000118171; ENSRNOP00000096153; ENSRNOG00000014653.
DR   GeneID; 364396; -.
DR   KEGG; rno:364396; -.
DR   UCSC; RGD:1308083; rat.
DR   CTD; 115761; -.
DR   RGD; 1308083; Arl11.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00940000162731; -.
DR   HOGENOM; CLU_040729_9_2_1; -.
DR   InParanoid; Q5BK71; -.
DR   OMA; WRKRDAR; -.
DR   OrthoDB; 1271528at2759; -.
DR   PhylomeDB; Q5BK71; -.
DR   TreeFam; TF105471; -.
DR   PRO; PR:Q5BK71; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000014653; Expressed in lung and 18 other tissues.
DR   Genevisible; Q5BK71; RN.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Lipoprotein; Myristate; Nucleotide-binding;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..173
FT                   /note="ADP-ribosylation factor-like protein 11"
FT                   /id="PRO_0000207481"
FT   BINDING         17..24
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         61..65
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         120..123
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   173 AA;  19156 MW;  6B4F024821D39E83 CRC64;
     MGSVNSRGHK AQVVMLGLDC AGKTTILYKL KGNRLVDTLP TVGFNVEPLE APGHVSLTLW
     DIGGQTQLRA TWKDYLEGID LLVYVLDSTD EARLPEAVAE LEEVLEDPNM AGVPFLVLAN
     KQEAPDALPL LEIRNRLDLE RFQDHCWELR ACSALTGQGL QEARQSLLHL LRS