ARL14_HUMAN
ID ARL14_HUMAN Reviewed; 192 AA.
AC Q8N4G2; Q9H655;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=ADP-ribosylation factor-like protein 14;
DE AltName: Full=ADP-ribosylation factor 7;
GN Name=ARL14; Synonyms=ARF7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, INTERACTION WITH ARL14EP, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=21458045; DOI=10.1016/j.cell.2011.03.023;
RA Paul P., van den Hoorn T., Jongsma M.L., Bakker M.J., Hengeveld R.,
RA Janssen L., Cresswell P., Egan D.A., van Ham M., Ten Brinke A., Ovaa H.,
RA Beijersbergen R.L., Kuijl C., Neefjes J.;
RT "A Genome-wide multidimensional RNAi screen reveals pathways controlling
RT MHC class II antigen presentation.";
RL Cell 145:268-283(2011).
CC -!- FUNCTION: GTPase that recruits MYO1E to MHC class II-containing
CC vesicles via the effector protein ARL14EP and hence controls the
CC movement of these vesicles along the actin cytoskeleton in dendritic
CC cells. {ECO:0000269|PubMed:21458045}.
CC -!- SUBUNIT: Interacts with ARL14EP. {ECO:0000269|PubMed:21458045}.
CC -!- INTERACTION:
CC Q8N4G2; Q8N8R7: ARL14EP; NbExp=3; IntAct=EBI-3921493, EBI-2807994;
CC Q8N4G2; Q86VI1: EXOC3L1; NbExp=3; IntAct=EBI-3921493, EBI-2813180;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC {ECO:0000269|PubMed:21458045}. Note=Colocalizes with MHC II-containing
CC cytoplasmic vesicles.
CC -!- TISSUE SPECIFICITY: Expressed in immature dendritic cells.
CC {ECO:0000269|PubMed:21458045}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; AK026248; BAB15411.1; -; mRNA.
DR EMBL; AC069224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034354; AAH34354.1; -; mRNA.
DR CCDS; CCDS3192.1; -.
DR RefSeq; NP_079323.1; NM_025047.2.
DR AlphaFoldDB; Q8N4G2; -.
DR SMR; Q8N4G2; -.
DR BioGRID; 123121; 5.
DR IntAct; Q8N4G2; 7.
DR STRING; 9606.ENSP00000323847; -.
DR iPTMnet; Q8N4G2; -.
DR PhosphoSitePlus; Q8N4G2; -.
DR BioMuta; ARL14; -.
DR DMDM; 296434398; -.
DR jPOST; Q8N4G2; -.
DR MassIVE; Q8N4G2; -.
DR PaxDb; Q8N4G2; -.
DR PeptideAtlas; Q8N4G2; -.
DR PRIDE; Q8N4G2; -.
DR ProteomicsDB; 71929; -.
DR Antibodypedia; 33672; 84 antibodies from 22 providers.
DR DNASU; 80117; -.
DR Ensembl; ENST00000320767.4; ENSP00000323847.2; ENSG00000179674.4.
DR GeneID; 80117; -.
DR KEGG; hsa:80117; -.
DR MANE-Select; ENST00000320767.4; ENSP00000323847.2; NM_025047.3; NP_079323.1.
DR UCSC; uc003fdq.4; human.
DR CTD; 80117; -.
DR DisGeNET; 80117; -.
DR GeneCards; ARL14; -.
DR HGNC; HGNC:22974; ARL14.
DR HPA; ENSG00000179674; Tissue enhanced (gallbladder, intestine, stomach).
DR MIM; 614439; gene.
DR neXtProt; NX_Q8N4G2; -.
DR OpenTargets; ENSG00000179674; -.
DR PharmGKB; PA134971739; -.
DR VEuPathDB; HostDB:ENSG00000179674; -.
DR eggNOG; KOG0070; Eukaryota.
DR GeneTree; ENSGT00940000162138; -.
DR HOGENOM; CLU_040729_9_2_1; -.
DR InParanoid; Q8N4G2; -.
DR OMA; RREFEHI; -.
DR OrthoDB; 1271528at2759; -.
DR PhylomeDB; Q8N4G2; -.
DR TreeFam; TF332600; -.
DR PathwayCommons; Q8N4G2; -.
DR SignaLink; Q8N4G2; -.
DR BioGRID-ORCS; 80117; 14 hits in 1069 CRISPR screens.
DR GenomeRNAi; 80117; -.
DR Pharos; Q8N4G2; Tbio.
DR PRO; PR:Q8N4G2; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8N4G2; protein.
DR Bgee; ENSG00000179674; Expressed in mucosa of sigmoid colon and 81 other tissues.
DR Genevisible; Q8N4G2; HS.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; GTP-binding; Lipoprotein; Myristate;
KW Nucleotide-binding; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..192
FT /note="ADP-ribosylation factor-like protein 14"
FT /id="PRO_0000281147"
FT BINDING 20..27
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 64..68
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 123..126
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT VARIANT 83
FT /note="D -> N (in dbSNP:rs35634980)"
FT /id="VAR_055521"
FT VARIANT 117
FT /note="P -> T (in dbSNP:rs35633732)"
FT /id="VAR_055522"
FT CONFLICT 58
FT /note="L -> F (in Ref. 3; AAH34354)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 21588 MW; DAA099214D8400DF CRC64;
MGSLGSKNPQ TKQAQVLLLG LDSAGKSTLL YKLKLAKDIT TIPTIGFNVE MIELERNLSL
TVWDVGGQEK MRTVWGCYCE NTDGLVYVVD STDKQRLEES QRQFEHILKN EHIKNVPVVL
LANKQDMPGA LTAEDITRMF KVKKLCSDRN WYVQPCCALT GEGLAQGFRK LTGFVKSHMK
SRGDTLAFFK QN
