ARL14_MOUSE
ID ARL14_MOUSE Reviewed; 192 AA.
AC Q3SXC5;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=ADP-ribosylation factor-like protein 14;
DE AltName: Full=ADP-ribosylation factor 7;
GN Name=Arl14; Synonyms=Arf7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: GTPase that recruits MYO1E to MHC class II-containing
CC vesicles via the effector protein ARL14EP and hence controls the
CC movement of these vesicles along the actin cytoskeleton in dendritic
CC cells. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ARL14EP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Colocalizes with MHC
CC II-containing cytoplasmic vesicles. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; BC104368; AAI04369.1; -; mRNA.
DR EMBL; BC104369; AAI04370.1; -; mRNA.
DR CCDS; CCDS59645.1; -.
DR AlphaFoldDB; Q3SXC5; -.
DR SMR; Q3SXC5; -.
DR STRING; 10090.ENSMUSP00000138370; -.
DR PhosphoSitePlus; Q3SXC5; -.
DR PRIDE; Q3SXC5; -.
DR ProteomicsDB; 283221; -.
DR MGI; MGI:1918869; Arl14.
DR eggNOG; KOG0070; Eukaryota.
DR InParanoid; Q3SXC5; -.
DR PhylomeDB; Q3SXC5; -.
DR PRO; PR:Q3SXC5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3SXC5; protein.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; GTP-binding; Lipoprotein; Myristate;
KW Nucleotide-binding; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..192
FT /note="ADP-ribosylation factor-like protein 14"
FT /id="PRO_0000281148"
FT BINDING 20..27
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 64..68
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 124..127
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 192 AA; 21835 MW; E8FAFF2C5D08DAE2 CRC64;
MGLLNSKNPQ SKQAHILLLG LDSAGKSTLL YRLKFAETLA TIPTIGFNVE MVQLQSSLTL
TVWDVGGQEK MRTVWDCYCE NAQGLMYVVD CSEGKKRLED SRKEFKHILK NEHIKNTPVV
ILANKQDLPG ALSAEDITRM FKVKKLCSNR NWYVQPCCAV TGEGLDDGFR KLTEFLKSYR
RTRETLAIFK QK
