ARL15_HUMAN
ID ARL15_HUMAN Reviewed; 204 AA.
AC Q9NXU5; Q6IAD0;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=ADP-ribosylation factor-like protein 15;
DE AltName: Full=ADP-ribosylation factor-related protein 2;
DE Short=ARF-related protein 2;
GN Name=ARL15; Synonyms=ARFRP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q9NXU5; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-711759, EBI-16439278;
CC Q9NXU5; O43924: PDE6D; NbExp=4; IntAct=EBI-711759, EBI-712685;
CC Q9NXU5; Q13432: UNC119; NbExp=4; IntAct=EBI-711759, EBI-711260;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; AK000058; BAA90915.1; -; mRNA.
DR EMBL; CR457225; CAG33506.1; -; mRNA.
DR EMBL; BC026093; AAH26093.1; -; mRNA.
DR CCDS; CCDS54850.1; -.
DR RefSeq; NP_061960.1; NM_019087.2.
DR AlphaFoldDB; Q9NXU5; -.
DR SMR; Q9NXU5; -.
DR BioGRID; 120080; 56.
DR IntAct; Q9NXU5; 29.
DR MINT; Q9NXU5; -.
DR STRING; 9606.ENSP00000433427; -.
DR iPTMnet; Q9NXU5; -.
DR PhosphoSitePlus; Q9NXU5; -.
DR SwissPalm; Q9NXU5; -.
DR BioMuta; ARL15; -.
DR DMDM; 74734700; -.
DR EPD; Q9NXU5; -.
DR jPOST; Q9NXU5; -.
DR MassIVE; Q9NXU5; -.
DR MaxQB; Q9NXU5; -.
DR PaxDb; Q9NXU5; -.
DR PeptideAtlas; Q9NXU5; -.
DR PRIDE; Q9NXU5; -.
DR ProteomicsDB; 83136; -.
DR Antibodypedia; 51587; 129 antibodies from 28 providers.
DR DNASU; 54622; -.
DR Ensembl; ENST00000504924.6; ENSP00000433427.1; ENSG00000185305.12.
DR GeneID; 54622; -.
DR KEGG; hsa:54622; -.
DR MANE-Select; ENST00000504924.6; ENSP00000433427.1; NM_019087.3; NP_061960.1.
DR UCSC; uc003jpg.1; human.
DR CTD; 54622; -.
DR DisGeNET; 54622; -.
DR GeneCards; ARL15; -.
DR HGNC; HGNC:25945; ARL15.
DR HPA; ENSG00000185305; Low tissue specificity.
DR neXtProt; NX_Q9NXU5; -.
DR OpenTargets; ENSG00000185305; -.
DR PharmGKB; PA134960964; -.
DR VEuPathDB; HostDB:ENSG00000185305; -.
DR eggNOG; KOG0071; Eukaryota.
DR GeneTree; ENSGT00940000156244; -.
DR InParanoid; Q9NXU5; -.
DR OrthoDB; 1446109at2759; -.
DR PhylomeDB; Q9NXU5; -.
DR TreeFam; TF329693; -.
DR PathwayCommons; Q9NXU5; -.
DR SignaLink; Q9NXU5; -.
DR BioGRID-ORCS; 54622; 22 hits in 1088 CRISPR screens.
DR ChiTaRS; ARL15; human.
DR GenomeRNAi; 54622; -.
DR Pharos; Q9NXU5; Tbio.
DR PRO; PR:Q9NXU5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9NXU5; protein.
DR Bgee; ENSG00000185305; Expressed in endothelial cell and 178 other tissues.
DR ExpressionAtlas; Q9NXU5; baseline and differential.
DR Genevisible; Q9NXU5; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR042292; ARL15.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR46693; PTHR46693; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51417; ARF; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..204
FT /note="ADP-ribosylation factor-like protein 15"
FT /id="PRO_0000282387"
FT BINDING 39..46
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 82..86
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 142..145
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT CONFLICT 204
FT /note="M -> I (in Ref. 2; CAG33506)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 22876 MW; 22CE5654057B734C CRC64;
MSDLRITEAF LYMDYLCFRA LCCKGPPPAR PEYDLVCIGL TGSGKTSLLS KLCSESPDNV
VSTTGFSIKA VPFQNAILNV KELGGADNIR KYWSRYYQGS QGVIFVLDSA SSEDDLEAAR
NELHSALQHP QLCTLPFLIL ANHQDKPAAR SVQEIKKYFE LEPLARGKRW ILQPCSLDDM
DALKDSFSQL INLLEEKDHE AVRM
