ARL15_MOUSE
ID ARL15_MOUSE Reviewed; 204 AA.
AC Q8BGR6;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=ADP-ribosylation factor-like protein 15;
DE AltName: Full=ADP-ribosylation factor-related protein 2;
DE Short=ARF-related protein 2;
GN Name=Arl15; Synonyms=Arfrp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Embryo, Heart, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Lung, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; AK039965; BAC30485.1; -; mRNA.
DR EMBL; AK048736; BAC33440.1; -; mRNA.
DR EMBL; AK050979; BAE20688.1; -; mRNA.
DR EMBL; AK052164; BAC34864.1; -; mRNA.
DR EMBL; BC120664; AAI20665.1; -; mRNA.
DR EMBL; BC120666; AAI20667.1; -; mRNA.
DR CCDS; CCDS36785.1; -.
DR RefSeq; NP_766183.1; NM_172595.4.
DR AlphaFoldDB; Q8BGR6; -.
DR SMR; Q8BGR6; -.
DR BioGRID; 230053; 4.
DR STRING; 10090.ENSMUSP00000088740; -.
DR iPTMnet; Q8BGR6; -.
DR PhosphoSitePlus; Q8BGR6; -.
DR SwissPalm; Q8BGR6; -.
DR EPD; Q8BGR6; -.
DR MaxQB; Q8BGR6; -.
DR PaxDb; Q8BGR6; -.
DR PRIDE; Q8BGR6; -.
DR ProteomicsDB; 274969; -.
DR Antibodypedia; 51587; 129 antibodies from 28 providers.
DR DNASU; 218639; -.
DR Ensembl; ENSMUST00000091201; ENSMUSP00000088740; ENSMUSG00000042348.
DR GeneID; 218639; -.
DR KEGG; mmu:218639; -.
DR UCSC; uc007rxj.1; mouse.
DR CTD; 54622; -.
DR MGI; MGI:2442308; Arl15.
DR VEuPathDB; HostDB:ENSMUSG00000042348; -.
DR eggNOG; KOG0071; Eukaryota.
DR GeneTree; ENSGT00940000156244; -.
DR HOGENOM; CLU_040729_13_0_1; -.
DR InParanoid; Q8BGR6; -.
DR OMA; CSENREN; -.
DR OrthoDB; 1446109at2759; -.
DR PhylomeDB; Q8BGR6; -.
DR TreeFam; TF329693; -.
DR BioGRID-ORCS; 218639; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Arl15; mouse.
DR PRO; PR:Q8BGR6; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8BGR6; protein.
DR Bgee; ENSMUSG00000042348; Expressed in manus and 220 other tissues.
DR ExpressionAtlas; Q8BGR6; baseline and differential.
DR Genevisible; Q8BGR6; MM.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR042292; ARL15.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR46693; PTHR46693; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51417; ARF; 1.
PE 1: Evidence at protein level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..204
FT /note="ADP-ribosylation factor-like protein 15"
FT /id="PRO_0000282388"
FT BINDING 39..46
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 82..86
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 142..145
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 204 AA; 22905 MW; 79A05BE1E05C9354 CRC64;
MSDLRITEAF LYMDYLCFRA LCCKGPPPAR PEYDLVCIGL TGSGKTSLLS ELCSESPENV
VSTTGFSIKA VPFQNAVLNV KELGGADNIR KYWSRYYQGS QGVIFVLDSA SSEDDLETAR
NELHSALQHP QLCTLPFLIL ANHQDKPAAR SVQEIKKYFE LEPLARGKRW ILQPCSLDDV
DTLKDSFSQL INLLEEKDHE AVRM
