ARL17_HUMAN
ID ARL17_HUMAN Reviewed; 177 AA.
AC Q8IVW1; B0AZR6; Q59FW5; Q8N6E2; Q8TD73; Q8WW54; Q9NZD5; Q9P158;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=ADP-ribosylation factor-like protein 17;
DE AltName: Full=ADP-ribosylation factor 7 variant;
GN Name=ARL17A; Synonyms=ARL17P1;
GN and
GN Name=ARL17B; Synonyms=ARF1P2, ARL17A; ORFNames=PRO2667;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Fetal liver;
RA Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.;
RT "Functional prediction of the coding sequences of 79 new genes deduced by
RT analysis of cDNA clones from human fetal liver.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Bone marrow;
RA Zhao M., Song H., Li N., Peng Y., Han Z., Chen Z.;
RT "A novel gene expressed in human bone marrow.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ILE-170.
RC TISSUE=Brain, Kidney, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: GTP-binding protein that functions as an allosteric activator
CC of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
CC Involved in protein trafficking; may modulate vesicle budding and
CC uncoating within the Golgi apparatus (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IVW1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IVW1-2; Sequence=VSP_008753;
CC Name=4;
CC IsoId=Q8IVW1-4; Sequence=VSP_008756;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF64278.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAF69643.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAH30570.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAD92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF119889; AAF69643.1; ALT_FRAME; mRNA.
DR EMBL; AF208864; AAF64278.1; ALT_FRAME; mRNA.
DR EMBL; AF493886; AAM12600.1; -; mRNA.
DR EMBL; AK315857; BAF98748.1; -; mRNA.
DR EMBL; AB209344; BAD92581.1; ALT_INIT; mRNA.
DR EMBL; BC030570; AAH30570.1; ALT_INIT; mRNA.
DR EMBL; BC041803; AAH41803.1; -; mRNA.
DR CCDS; CCDS54137.1; -. [Q8IVW1-2]
DR CCDS; CCDS58557.1; -. [Q8IVW1-1]
DR RefSeq; NP_001034172.3; NM_001039083.3. [Q8IVW1-1]
DR RefSeq; NP_001096624.1; NM_001103154.1. [Q8IVW1-2]
DR RefSeq; NP_001107210.1; NM_001113738.1. [Q8IVW1-1]
DR RefSeq; NP_001275741.1; NM_001288812.1. [Q8IVW1-2]
DR RefSeq; NP_057716.2; NM_016632.2. [Q8IVW1-2]
DR RefSeq; XP_005256975.1; XM_005256918.4.
DR RefSeq; XP_005257496.1; XM_005257439.4. [Q8IVW1-2]
DR RefSeq; XP_006725347.1; XM_006725284.3. [Q8IVW1-2]
DR RefSeq; XP_011523177.1; XM_011524875.2. [Q8IVW1-4]
DR AlphaFoldDB; Q8IVW1; -.
DR SMR; Q8IVW1; -.
DR BioGRID; 119475; 18.
DR IntAct; Q8IVW1; 2.
DR STRING; 9606.ENSP00000337478; -.
DR iPTMnet; Q8IVW1; -.
DR PhosphoSitePlus; Q8IVW1; -.
DR BioMuta; ARL17A; -.
DR DMDM; 93141230; -.
DR jPOST; Q8IVW1; -.
DR MassIVE; Q8IVW1; -.
DR MaxQB; Q8IVW1; -.
DR PaxDb; Q8IVW1; -.
DR PeptideAtlas; Q8IVW1; -.
DR PRIDE; Q8IVW1; -.
DR Antibodypedia; 45114; 33 antibodies from 10 providers.
DR Antibodypedia; 73103; 38 antibodies from 5 providers.
DR DNASU; 100506084; -.
DR Ensembl; ENST00000336125.6; ENSP00000337478.6; ENSG00000185829.18. [Q8IVW1-1]
DR Ensembl; ENST00000434041.6; ENSP00000391751.2; ENSG00000228696.10. [Q8IVW1-2]
DR Ensembl; ENST00000445552.6; ENSP00000416535.2; ENSG00000185829.18. [Q8IVW1-2]
DR Ensembl; ENST00000450673.4; ENSP00000404247.4; ENSG00000228696.10. [Q8IVW1-1]
DR Ensembl; ENST00000570618.5; ENSP00000459151.1; ENSG00000228696.10. [Q8IVW1-2]
DR Ensembl; ENST00000613440.4; ENSP00000482789.1; ENSG00000275748.4. [Q8IVW1-2]
DR Ensembl; ENST00000615623.4; ENSP00000482856.1; ENSG00000276276.4. [Q8IVW1-2]
DR Ensembl; ENST00000617818.4; ENSP00000479224.1; ENSG00000276276.4. [Q8IVW1-2]
DR Ensembl; ENST00000618729.2; ENSP00000483271.1; ENSG00000276276.4. [Q8IVW1-1]
DR Ensembl; ENST00000622165.3; ENSP00000481838.1; ENSG00000275748.4. [Q8IVW1-1]
DR Ensembl; ENST00000626328.2; ENSP00000487334.1; ENSG00000275748.4. [Q8IVW1-2]
DR Ensembl; ENST00000634170.1; ENSP00000487605.1; ENSG00000276276.4. [Q8IVW1-2]
DR Ensembl; ENST00000656849.1; ENSP00000499587.1; ENSG00000228696.10. [Q8IVW1-2]
DR GeneID; 100506084; -.
DR GeneID; 100996709; -.
DR GeneID; 51326; -.
DR KEGG; hsa:100506084; -.
DR KEGG; hsa:100996709; -.
DR KEGG; hsa:51326; -.
DR MANE-Select; ENST00000336125.6; ENSP00000337478.6; NM_001113738.2; NP_001107210.1.
DR MANE-Select; ENST00000450673.4; ENSP00000404247.4; NM_001039083.5; NP_001034172.3.
DR UCSC; uc002ikk.4; human. [Q8IVW1-1]
DR CTD; 100506084; -.
DR CTD; 51326; -.
DR DisGeNET; 100506084; -.
DR DisGeNET; 51326; -.
DR GeneCards; ARL17A; -.
DR GeneCards; ARL17B; -.
DR HGNC; HGNC:24096; ARL17A.
DR HGNC; HGNC:32387; ARL17B.
DR HPA; ENSG00000185829; Low tissue specificity.
DR HPA; ENSG00000228696; Low tissue specificity.
DR neXtProt; NX_Q8IVW1; -.
DR OpenTargets; ENSG00000185829; -.
DR OpenTargets; ENSG00000228696; -.
DR PharmGKB; PA165431478; -.
DR VEuPathDB; HostDB:ENSG00000185829; -.
DR VEuPathDB; HostDB:ENSG00000228696; -.
DR eggNOG; KOG0070; Eukaryota.
DR GeneTree; ENSGT00950000183080; -.
DR HOGENOM; CLU_040729_15_1_1; -.
DR InParanoid; Q8IVW1; -.
DR OrthoDB; 1362554at2759; -.
DR PhylomeDB; Q8IVW1; -.
DR TreeFam; TF300808; -.
DR TreeFam; TF341532; -.
DR PathwayCommons; Q8IVW1; -.
DR SignaLink; Q8IVW1; -.
DR BioGRID-ORCS; 100506084; 15 hits in 268 CRISPR screens.
DR BioGRID-ORCS; 100996709; 0 hits in 3 CRISPR screens.
DR BioGRID-ORCS; 51326; 17 hits in 637 CRISPR screens.
DR ChiTaRS; ARL17A; human.
DR ChiTaRS; ARL17B; human.
DR Pharos; Q8IVW1; Tdark.
DR PRO; PR:Q8IVW1; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8IVW1; protein.
DR Bgee; ENSG00000185829; Expressed in right uterine tube and 100 other tissues.
DR ExpressionAtlas; Q8IVW1; baseline and differential.
DR Genevisible; Q8IVW1; HS.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR031687; ARL17_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR Pfam; PF15840; ARL17; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ER-Golgi transport; Golgi apparatus; GTP-binding;
KW Lipoprotein; Myristate; Nucleotide-binding; Protein transport;
KW Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..177
FT /note="ADP-ribosylation factor-like protein 17"
FT /id="PRO_0000207482"
FT BINDING 24..31
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 67..71
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 87..177
FT /note="GARSPGSTHQGSLASGVLPIKCSHVEFGMWKGGRSHPFLPHSSRCAGSGGQL
FT DSILPHQSPAWGPWGCKDLSSGFPSFLTSSILWKSAVVK -> ELSASQFAQFIKKLCG
FT VTGTNDEASPGSLTSYPSHLLDR (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2, ECO:0000303|Ref.3"
FT /id="VSP_008753"
FT VAR_SEQ 176..177
FT /note="VK -> SYQLPSLHNSSRNYAGSPAQMMRHLLEA (in isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_008756"
FT VARIANT 170
FT /note="L -> I"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_017170"
FT CONFLICT 75
FT /note="R -> G (in Ref. 2; AAF64278)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 177 AA; 19388 MW; D9AE68B0C19ABBAE CRC64;
MGNIFEKLFK SLLGKKKMRI LILSLDTAGK TTILYKLKLG ETVPAVPTVG FCVETVEYKN
NTFAVWDVGS HFKIRPLWQH FFQNTKGARS PGSTHQGSLA SGVLPIKCSH VEFGMWKGGR
SHPFLPHSSR CAGSGGQLDS ILPHQSPAWG PWGCKDLSSG FPSFLTSSIL WKSAVVK
