ARL1_CAEEL
ID ARL1_CAEEL Reviewed; 180 AA.
AC Q20758;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=ADP-ribosylation factor-like protein 1;
GN Name=arl-1 {ECO:0000312|WormBase:F54C9.10};
GN ORFNames=F54C9.10 {ECO:0000312|WormBase:F54C9.10};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=21408209; DOI=10.1371/journal.pgen.1002010;
RA Nelson M.D., Zhou E., Kiontke K., Fradin H., Maldonado G., Martin D.,
RA Shah K., Fitch D.H.;
RT "A bow-tie genetic architecture for morphogenesis suggested by a genome-
RT wide RNAi screen in Caenorhabditis elegans.";
RL PLoS Genet. 7:E1002010-E1002010(2011).
CC -!- FUNCTION: GTP-binding protein that may be involved in protein
CC trafficking; may modulate vesicle budding and uncoating within the
CC Golgi apparatus. Plays a role in male tail tip morphogenesis
CC (PubMed:21408209). {ECO:0000250, ECO:0000269|PubMed:21408209}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasm
CC {ECO:0000269|PubMed:21408209}. Cytoplasmic granule
CC {ECO:0000269|PubMed:21408209}. Note=Localizes to cytoplasmic granules
CC (puncta) during the later stage of male tail tip retraction.
CC {ECO:0000269|PubMed:21408209}.
CC -!- TISSUE SPECIFICITY: Expressed in neuronal cells (PubMed:21408209).
CC Expression in hypodermal tissues is absent (PubMed:21408209).
CC {ECO:0000269|PubMed:21408209}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels in hyp8-11 tail tip cells
CC during the early L4 larval stage (PubMed:21408209). Occassionally,
CC expression is high in hyp10 tail top cells during this time
CC (PubMed:21408209). {ECO:0000269|PubMed:21408209}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in male tail tip
CC defects. {ECO:0000269|PubMed:21408209}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; BX284602; CAA90255.1; -; Genomic_DNA.
DR PIR; T22635; T22635.
DR RefSeq; NP_495816.1; NM_063415.6.
DR AlphaFoldDB; Q20758; -.
DR SMR; Q20758; -.
DR BioGRID; 39703; 3.
DR STRING; 6239.F54C9.10.2; -.
DR EPD; Q20758; -.
DR PaxDb; Q20758; -.
DR PeptideAtlas; Q20758; -.
DR EnsemblMetazoa; F54C9.10.1; F54C9.10.1; WBGene00000187.
DR GeneID; 174375; -.
DR KEGG; cel:CELE_F54C9.10; -.
DR UCSC; F54C9.10.1; c. elegans.
DR CTD; 174375; -.
DR WormBase; F54C9.10; CE02250; WBGene00000187; arl-1.
DR eggNOG; KOG0072; Eukaryota.
DR GeneTree; ENSGT00940000155118; -.
DR HOGENOM; CLU_040729_9_3_1; -.
DR InParanoid; Q20758; -.
DR OMA; QEGMDWL; -.
DR OrthoDB; 1271528at2759; -.
DR PhylomeDB; Q20758; -.
DR Reactome; R-CEL-6811440; Retrograde transport at the Trans-Golgi-Network.
DR PRO; PR:Q20758; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00000187; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0110039; P:positive regulation of nematode male tail tip morphogenesis; IMP:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein;
KW Myristate; Nucleotide-binding; Protein transport; Reference proteome;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..180
FT /note="ADP-ribosylation factor-like protein 1"
FT /id="PRO_0000207406"
FT BINDING 23..30
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 66..70
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 180 AA; 20104 MW; D93C88E3C26D64B9 CRC64;
MGGVMSYFRG LFGAREMRIL ILGLDGAGKT TILYRLQVGE VVTTIPTIGF NVEQVEYKNL
KFQVWDLGGQ TSIRPYWRCY YANTDAIIYV VDSADRDRVG ISRQELATML QEDELQGAVL
AVLANKQDIA GCLTETEVYK ALGLDALRNR TIQIFKTSAS KGEGLDPAMD WLANQLQQKK
