ARL1_DROME
ID ARL1_DROME Reviewed; 180 AA.
AC P25160; Q9VUW7;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 5.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=ADP-ribosylation factor-like protein 1;
GN Name=Arl1; Synonyms=Arf72A, arl; ORFNames=CG6025;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1901655; DOI=10.1073/pnas.88.8.3120;
RA Tamkun J.W., Kahn R.A., Kissinger M., Brizuela B.J., Rulka C., Scott M.P.,
RA Kennison J.A.;
RT "The arflike gene encodes an essential GTP-binding protein in Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:3120-3124(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Ovary;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: GTP-binding protein involved in protein trafficking; may
CC modulate vesicle budding and uncoating within the Golgi apparatus.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; M61127; AAA28365.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF49556.2; -; Genomic_DNA.
DR EMBL; BT001460; AAN71215.1; -; mRNA.
DR PIR; A40438; A40438.
DR RefSeq; NP_524098.2; NM_079374.4.
DR AlphaFoldDB; P25160; -.
DR SMR; P25160; -.
DR BioGRID; 65056; 15.
DR DIP; DIP-21617N; -.
DR IntAct; P25160; 2.
DR STRING; 7227.FBpp0075272; -.
DR PaxDb; P25160; -.
DR PRIDE; P25160; -.
DR DNASU; 39745; -.
DR EnsemblMetazoa; FBtr0075517; FBpp0075272; FBgn0000115.
DR GeneID; 39745; -.
DR KEGG; dme:Dmel_CG6025; -.
DR CTD; 400; -.
DR FlyBase; FBgn0000115; Arl1.
DR VEuPathDB; VectorBase:FBgn0000115; -.
DR eggNOG; KOG0072; Eukaryota.
DR GeneTree; ENSGT00940000155118; -.
DR HOGENOM; CLU_040729_9_3_1; -.
DR InParanoid; P25160; -.
DR OMA; QEGMDWL; -.
DR OrthoDB; 1271528at2759; -.
DR PhylomeDB; P25160; -.
DR Reactome; R-DME-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 39745; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Arl1; fly.
DR GenomeRNAi; 39745; -.
DR PRO; PR:P25160; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0000115; Expressed in male reproductive gland and 26 other tissues.
DR Genevisible; P25160; DM.
DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0005802; C:trans-Golgi network; IDA:FlyBase.
DR GO; GO:0005525; F:GTP binding; IDA:FlyBase.
DR GO; GO:0003924; F:GTPase activity; ISS:FlyBase.
DR GO; GO:0019904; F:protein domain specific binding; IPI:FlyBase.
DR GO; GO:0033227; P:dsRNA transport; IMP:FlyBase.
DR GO; GO:0090158; P:endoplasmic reticulum membrane organization; IMP:FlyBase.
DR GO; GO:0007030; P:Golgi organization; IMP:FlyBase.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0007269; P:neurotransmitter secretion; TAS:FlyBase.
DR GO; GO:0034067; P:protein localization to Golgi apparatus; IMP:FlyBase.
DR GO; GO:1903292; P:protein localization to Golgi membrane; IDA:FlyBase.
DR GO; GO:0030334; P:regulation of cell migration; IMP:FlyBase.
DR GO; GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; IMP:FlyBase.
DR GO; GO:0070861; P:regulation of protein exit from endoplasmic reticulum; IMP:FlyBase.
DR GO; GO:0007431; P:salivary gland development; IMP:FlyBase.
DR GO; GO:0033363; P:secretory granule organization; IMP:FlyBase.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; TAS:FlyBase.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0035220; P:wing disc development; IMP:FlyBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Lipoprotein; Myristate; Nucleotide-binding;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..180
FT /note="ADP-ribosylation factor-like protein 1"
FT /id="PRO_0000207448"
FT BINDING 23..30
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 66..70
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 180 AA; 20247 MW; D9B1DE83D37201C5 CRC64;
MGGVLSYFRG LLGSREMRIL ILGLDGAGKT TILYRLQVGE VVTTIPTIGF NVEQVTYKNL
KFQVWDLGGQ TSIRPYWRCY YSNTDAIIYV VDSADRDRIG ISKDELLYML REEELAGAIL
VVLANKQDMD GCMTVAEVHH ALGLENLKNR TFQIFKTSAT KGEGLDQAMD WLSNTLQSRK
