ARL2_CAEBR
ID ARL2_CAEBR Reviewed; 184 AA.
AC Q627K4; A8WLV4;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=ADP-ribosylation factor-like protein 2;
DE AltName: Full=Abnormal eversion of vulva protein 20;
GN Name=evl-20.1; Synonyms=arl-2.1; ORFNames=CBG00634;
GN and
GN Name=evl-20.2; Synonyms=arl-2.2; ORFNames=CBG24969;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: GTP-binding protein that functions in embryogenesis,
CC cytokinesis, germline development and microtubulule cytoskeleton
CC dynamics. {ECO:0000250|UniProtKB:Q19705}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q19705}. Cell
CC membrane {ECO:0000250|UniProtKB:Q19705}. Cytoplasm, cytoskeleton,
CC microtubule organizing center, centrosome {ECO:0000250}. Note=Some
CC diffuse cytoplasmic expression is detected but expression is
CC concentrated mainly next to centrosomes and is excluded from the
CC mitotic spindle area. Localizes to the cortical plasma membrane of
CC embryonic blastomeres (By similarity). {ECO:0000250|UniProtKB:Q19705}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000255}.
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DR EMBL; HE601195; CAP21452.1; -; Genomic_DNA.
DR EMBL; HE600999; CAP22001.1; -; Genomic_DNA.
DR RefSeq; XP_002630221.1; XM_002630175.1.
DR RefSeq; XP_002648624.1; XM_002648578.1.
DR AlphaFoldDB; Q627K4; -.
DR SMR; Q627K4; -.
DR STRING; 6238.CBG00634; -.
DR PRIDE; Q627K4; -.
DR EnsemblMetazoa; CBG00634.1; CBG00634.1; WBGene00024000.
DR EnsemblMetazoa; CBG24969.1; CBG24969.1; WBGene00042955.
DR GeneID; 8571736; -.
DR GeneID; 8590629; -.
DR KEGG; cbr:CBG_00634; -.
DR KEGG; cbr:CBG_24969; -.
DR CTD; 8571736; -.
DR CTD; 8590629; -.
DR WormBase; CBG00634; CBP00190; WBGene00024000; Cbr-evl-20.1.
DR WormBase; CBG24969; CBP00190; WBGene00042955; Cbr-evl-20.2.
DR eggNOG; KOG0073; Eukaryota.
DR HOGENOM; CLU_040729_12_3_1; -.
DR InParanoid; Q627K4; -.
DR OMA; EHRGYKL; -.
DR OrthoDB; 1271528at2759; -.
DR Proteomes; UP000008549; Chromosome II.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0043622; P:cortical microtubule organization; ISS:UniProtKB.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR GO; GO:0030540; P:female genitalia development; ISS:UniProtKB.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR CDD; cd04154; Arl2; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR045873; Arl2.
DR InterPro; IPR044612; ARL2/3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR45697; PTHR45697; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell membrane; Cytoplasm; Cytoskeleton;
KW Developmental protein; GTP-binding; Lipoprotein; Membrane; Myristate;
KW Nucleotide-binding; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..184
FT /note="ADP-ribosylation factor-like protein 2"
FT /id="PRO_0000282947"
FT BINDING 23..30
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D0J4"
FT BINDING 66..70
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D0J4"
FT BINDING 68
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D0J4"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9D0J4"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 184 AA; 21107 MW; 472330717E91E0FB CRC64;
MGFLKILRKQ RAREREMRIL ILGLDNAGKT TLMKKFLDEP TDTIEPTLGF DIKTVHFKDF
QLNLWDVGGQ KSLRSYWKNY FESTDALIWV VDSSDRERLT QCSEELKKLL QEERLSGASL
LVLANKSDLP GAIDVNSIAQ VLELQSIKTH HWKIFSCCAL SGERLVQAMT WLCDDVGSRI
FILD
