ID   ARL3_CAEEL              Reviewed;         184 AA.
AC   O45379;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=ADP-ribosylation factor-like protein 3;
GN   Name=arl-3; ORFNames=F19H8.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: GTP-binding protein that may be involved in protein
CC       trafficking; may modulate vesicle budding and uncoating within the
CC       Golgi apparatus. {ECO:0000250}.
CC   -!- INTERACTION:
CC       O45379; Q18268: pdl-1; NbExp=4; IntAct=EBI-325438, EBI-316181;
CC       O45379; Q10658: unc-119; NbExp=5; IntAct=EBI-325438, EBI-325431;
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; Z93378; CAB07583.1; -; Genomic_DNA.
DR   PIR; T21126; T21126.
DR   RefSeq; NP_497037.1; NM_064636.1.
DR   AlphaFoldDB; O45379; -.
DR   SMR; O45379; -.
DR   BioGRID; 40402; 5.
DR   DIP; DIP-24793N; -.
DR   IntAct; O45379; 3.
DR   STRING; 6239.F19H8.3; -.
DR   EPD; O45379; -.
DR   PaxDb; O45379; -.
DR   PeptideAtlas; O45379; -.
DR   PRIDE; O45379; -.
DR   EnsemblMetazoa; F19H8.3.1; F19H8.3.1; WBGene00000188.
DR   GeneID; 175121; -.
DR   KEGG; cel:CELE_F19H8.3; -.
DR   UCSC; F19H8.3; c. elegans.
DR   CTD; 175121; -.
DR   WormBase; F19H8.3; CE15872; WBGene00000188; arl-3.
DR   eggNOG; KOG0074; Eukaryota.
DR   GeneTree; ENSGT00940000173608; -.
DR   HOGENOM; CLU_040729_12_0_1; -.
DR   InParanoid; O45379; -.
DR   OMA; ASEDITQ; -.
DR   PhylomeDB; O45379; -.
DR   Reactome; R-CEL-5624138; Trafficking of myristoylated proteins to the cilium.
DR   PRO; PR:O45379; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00000188; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR044612; ARL2/3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR45697; PTHR45697; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   1: Evidence at protein level;
KW   ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Myristate;
KW   Nucleotide-binding; Protein transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..184
FT                   /note="ADP-ribosylation factor-like protein 3"
FT                   /id="PRO_0000207407"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         68..72
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         127..130
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   184 AA;  20771 MW;  796818879C2F3004 CRC64;
     MGLIDVLKSF KSPSGREIRI LLLGLDNAGK TTILKQLSSE DVQHVTPTKG FNVKTVAAMG
     DIRLNVWDIG GQRSIRPYWS NYYENIDTLI FVIDSNDKKR FDEMNIELGE LLDEEKLRKV
     PVLIFANKQD LVTAASSEEI TRKLNLDLLR DRTWHIQACS ALKNEGINDG ITWVASNLKP
     ASKK