ID   ARL4A_BOVIN             Reviewed;         200 AA.
AC   Q3T0M9;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=ADP-ribosylation factor-like protein 4A;
GN   Name=ARL4A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTP-binding protein which cycles between an inactive
CC       GDP-bound and an active GTP-bound form, and the rate of cycling is
CC       regulated by guanine nucleotide exchange factors (GEF) and GTPase-
CC       activating proteins (GAP). GTP-binding protein that does not act as an
CC       allosteric activator of the cholera toxin catalytic subunit. Recruits
CC       CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CYTH2. Interacts with KPNA2; the interaction is
CC       direct. Does not interacts with ARL4A (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Localization in
CC       the nucleolus is dependent by nucleotide binding. {ECO:0000250}.
CC   -!- PTM: Myristoylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; BC102325; AAI02326.1; -; mRNA.
DR   RefSeq; NP_001070453.1; NM_001076985.2.
DR   RefSeq; XP_005205270.1; XM_005205213.2.
DR   RefSeq; XP_005205271.1; XM_005205214.2.
DR   RefSeq; XP_005205272.1; XM_005205215.3.
DR   RefSeq; XP_005205273.1; XM_005205216.3.
DR   AlphaFoldDB; Q3T0M9; -.
DR   SMR; Q3T0M9; -.
DR   STRING; 9913.ENSBTAP00000003722; -.
DR   PaxDb; Q3T0M9; -.
DR   PRIDE; Q3T0M9; -.
DR   Ensembl; ENSBTAT00000003722; ENSBTAP00000003722; ENSBTAG00000002869.
DR   GeneID; 767906; -.
DR   KEGG; bta:767906; -.
DR   CTD; 10124; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002869; -.
DR   VGNC; VGNC:26144; ARL4A.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00940000154546; -.
DR   HOGENOM; CLU_040729_9_3_1; -.
DR   InParanoid; Q3T0M9; -.
DR   OMA; FEWIAAN; -.
DR   OrthoDB; 1457094at2759; -.
DR   TreeFam; TF105464; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000002869; Expressed in spermatid and 105 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; GTP-binding; Lipoprotein; Membrane; Myristate;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..200
FT                   /note="ADP-ribosylation factor-like protein 4A"
FT                   /id="PRO_0000245355"
FT   BINDING         27..34
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         75..79
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   200 AA;  22588 MW;  8D82542D0F5CEA22 CRC64;
     MGNGLSDQTS ILSSLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP TKGFNTEKIK
     VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV DSVDVERMEE AKTELHKITR
     ISENQGVPVL IVANKQDLRN SLSLSEIEKL LAMGELSSST PWHLQPTCAI IGDGLKEGLE
     KLHDMIIKRR KMLRQQKKKR