ID   ARL4D_BOVIN             Reviewed;         200 AA.
AC   Q0VC18;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=ADP-ribosylation factor-like protein 4D;
GN   Name=ARL4D;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTP-binding protein which cycles between an inactive
CC       GDP-bound and an active GTP-bound form, and the rate of cycling is
CC       regulated by guanine nucleotide exchange factors (GEF) and GTPase-
CC       activating proteins (GAP). GTP-binding protein that does not act as an
CC       allosteric activator of the cholera toxin catalytic subunit. Recruits
CC       CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CYTH2; the interaction is direct and ARL4D GTP-
CC       dependent. Does not interact with ARL4D (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cell membrane.
CC       Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; BC120393; AAI20394.1; -; mRNA.
DR   RefSeq; NP_001069603.1; NM_001076135.1.
DR   AlphaFoldDB; Q0VC18; -.
DR   SMR; Q0VC18; -.
DR   STRING; 9913.ENSBTAP00000022409; -.
DR   PaxDb; Q0VC18; -.
DR   PRIDE; Q0VC18; -.
DR   Ensembl; ENSBTAT00000022409; ENSBTAP00000022409; ENSBTAG00000016847.
DR   GeneID; 538936; -.
DR   KEGG; bta:538936; -.
DR   CTD; 379; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016847; -.
DR   VGNC; VGNC:26146; ARL4D.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00940000161341; -.
DR   HOGENOM; CLU_040729_9_2_1; -.
DR   InParanoid; Q0VC18; -.
DR   OMA; PSFQCLH; -.
DR   OrthoDB; 1457094at2759; -.
DR   TreeFam; TF105464; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000016847; Expressed in liver and 100 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; GTP-binding; Lipoprotein; Membrane; Myristate;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..200
FT                   /note="ADP-ribosylation factor-like protein 4D"
FT                   /id="PRO_0000282339"
FT   BINDING         27..34
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         75..79
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   200 AA;  22126 MW;  B8B28C74677A7764 CRC64;
     MGNHLTEMAP TTSFLPHFQA LHVVVIGLDS AGKTSLLYRL KFKEFVQSIP TKGFNTEKIR
     VPLGGSRGIT FQVWDVGGQE KLRPLWRSYT RRTDGLVFVV DAAEAERLEE AKVELHRISR
     ASDNQGVPVL VLANKQDQPG ALSAAEVEKR LAVRELATAT LTHVQGCSAV DGLGLQPGLE
     RLYEMILKRK KAARAGKKRR