ID   METE_THEKO              Reviewed;         336 AA.
AC   Q5JH51;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Methionine synthase {ECO:0000255|HAMAP-Rule:MF_00288};
DE            EC=2.1.1.- {ECO:0000255|HAMAP-Rule:MF_00288};
DE   AltName: Full=Homocysteine methyltransferase {ECO:0000255|HAMAP-Rule:MF_00288};
GN   Name=metE {ECO:0000255|HAMAP-Rule:MF_00288}; OrderedLocusNames=TK1446;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Catalyzes the transfer of a methyl group to L-homocysteine
CC       resulting in methionine formation. The physiological methyl donor is
CC       unknown. {ECO:0000255|HAMAP-Rule:MF_00288}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00288};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00288};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway. {ECO:0000255|HAMAP-Rule:MF_00288}.
CC   -!- SIMILARITY: Belongs to the archaeal MetE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00288, ECO:0000305}.
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DR   EMBL; AP006878; BAD85635.1; -; Genomic_DNA.
DR   RefSeq; WP_011250397.1; NC_006624.1.
DR   AlphaFoldDB; Q5JH51; -.
DR   SMR; Q5JH51; -.
DR   STRING; 69014.TK1446; -.
DR   EnsemblBacteria; BAD85635; BAD85635; TK1446.
DR   GeneID; 3235806; -.
DR   KEGG; tko:TK1446; -.
DR   PATRIC; fig|69014.16.peg.1408; -.
DR   eggNOG; arCOG01876; Archaea.
DR   HOGENOM; CLU_040013_3_2_2; -.
DR   InParanoid; Q5JH51; -.
DR   OMA; DPDCGMR; -.
DR   OrthoDB; 21172at2157; -.
DR   PhylomeDB; Q5JH51; -.
DR   UniPathway; UPA00051; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd03311; CIMS_C_terminal_like; 1.
DR   Gene3D; 3.20.20.210; -; 1.
DR   HAMAP; MF_00288; MetE; 1.
DR   InterPro; IPR002629; Met_Synth_C/arc.
DR   InterPro; IPR022921; MetE_arc.
DR   InterPro; IPR038071; UROD/MetE-like_sf.
DR   Pfam; PF01717; Meth_synt_2; 1.
DR   SUPFAM; SSF51726; SSF51726; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Metal-binding; Methionine biosynthesis;
KW   Methyltransferase; Reference proteome; Transferase; Zinc.
FT   CHAIN           1..336
FT                   /note="Methionine synthase"
FT                   /id="PRO_0000098690"
FT   BINDING         210
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00288"
FT   BINDING         212
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00288"
FT   BINDING         234
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00288"
FT   BINDING         294
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00288"
SQ   SEQUENCE   336 AA;  39054 MW;  37A65C2BC9440915 CRC64;
     MELPILPTSI IGSYPKPRWL LRMYNLRELG RLPEEDFREA VRDASVAVLR EHERAGIDIP
     WDGEMGRSEM TEYFTAKIAG FKFYGPIRVW GNAYFNKAAA VSKLEYREPL VLDEFRWVKE
     NTTREIIKVP ITGPYTIAEW SFNEYYSSKE ELAFDLAKIL NKEFKLLEKE GATFIQIDEP
     AMLNHPDEVS IAVEAINRAV KGVKVKFGLH VCYSNYYLLA DYFDDIKVSQ FALEAANRNF
     RDLDYLKKLT HQELGFGVVD VHNPRVESPE EVAKAIRKVM EYIEPERLYI NPDCGLKLLD
     RRIAYQKLVN MVKGVEIVRR ELAREGKTSI PFRREV