ID   ARL4D_PONAB             Reviewed;         201 AA.
AC   Q5REU3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=ADP-ribosylation factor-like protein 4D;
DE   AltName: Full=ADP-ribosylation factor-like protein 4L;
GN   Name=ARL4D; Synonyms=ARF4L;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTP-binding protein which cycles between an inactive
CC       GDP-bound and an active GTP-bound form, and the rate of cycling is
CC       regulated by guanine nucleotide exchange factors (GEF) and GTPase-
CC       activating proteins (GAP). GTP-binding protein that does not act as an
CC       allosteric activator of the cholera toxin catalytic subunit. Recruits
CC       CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CYTH2; the interaction is direct and ARL4D GTP-
CC       dependent. Does not interact with ARL4D (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cell membrane.
CC       Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; CR857423; CAH89714.1; -; mRNA.
DR   RefSeq; NP_001124778.1; NM_001131306.1.
DR   AlphaFoldDB; Q5REU3; -.
DR   SMR; Q5REU3; -.
DR   STRING; 9601.ENSPPYP00000009396; -.
DR   Ensembl; ENSPPYT00000009773; ENSPPYP00000009396; ENSPPYG00000008358.
DR   GeneID; 100171631; -.
DR   KEGG; pon:100171631; -.
DR   CTD; 379; -.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00940000161341; -.
DR   HOGENOM; CLU_040729_9_2_1; -.
DR   InParanoid; Q5REU3; -.
DR   OMA; PSFQCLH; -.
DR   OrthoDB; 1457094at2759; -.
DR   TreeFam; TF105464; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; GTP-binding; Lipoprotein; Membrane; Myristate;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..201
FT                   /note="ADP-ribosylation factor-like protein 4D"
FT                   /id="PRO_0000207466"
FT   BINDING         28..35
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         76..80
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         135..138
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   201 AA;  22156 MW;  18766BCF56A8127D CRC64;
     MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI
     RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDAAEAERLE EAKVELHRIS
     RASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VDGLGLQQGL
     ERLYEMILKR KKAARGGKKR R