ID   ARL5A_MOUSE             Reviewed;         179 AA.
AC   Q80ZU0;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=ADP-ribosylation factor-like protein 5A;
GN   Name=Arl5a; Synonyms=Arl5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, and Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Lacks ADP-ribosylation enhancing activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; BC048170; AAH48170.1; -; mRNA.
DR   CCDS; CCDS16033.1; -.
DR   RefSeq; NP_892039.1; NM_182994.2.
DR   AlphaFoldDB; Q80ZU0; -.
DR   SMR; Q80ZU0; -.
DR   STRING; 10090.ENSMUSP00000041756; -.
DR   PhosphoSitePlus; Q80ZU0; -.
DR   MaxQB; Q80ZU0; -.
DR   PaxDb; Q80ZU0; -.
DR   PRIDE; Q80ZU0; -.
DR   ProteomicsDB; 283223; -.
DR   Antibodypedia; 33675; 65 antibodies from 16 providers.
DR   DNASU; 75423; -.
DR   Ensembl; ENSMUST00000036541; ENSMUSP00000041756; ENSMUSG00000036093.
DR   GeneID; 75423; -.
DR   KEGG; mmu:75423; -.
DR   UCSC; uc008jqy.1; mouse.
DR   CTD; 26225; -.
DR   MGI; MGI:1922673; Arl5a.
DR   VEuPathDB; HostDB:ENSMUSG00000036093; -.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00940000154714; -.
DR   HOGENOM; CLU_040729_9_1_1; -.
DR   InParanoid; Q80ZU0; -.
DR   OMA; IWRLFSH; -.
DR   OrthoDB; 1417432at2759; -.
DR   PhylomeDB; Q80ZU0; -.
DR   TreeFam; TF105465; -.
DR   BioGRID-ORCS; 75423; 1 hit in 70 CRISPR screens.
DR   ChiTaRS; Arl5a; mouse.
DR   PRO; PR:Q80ZU0; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q80ZU0; protein.
DR   Bgee; ENSMUSG00000036093; Expressed in optic fissure and 272 other tissues.
DR   ExpressionAtlas; Q80ZU0; baseline and differential.
DR   Genevisible; Q80ZU0; MM.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:1903292; P:protein localization to Golgi membrane; ISO:MGI.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   1: Evidence at protein level;
KW   GTP-binding; Lipoprotein; Myristate; Nucleotide-binding;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..179
FT                   /note="ADP-ribosylation factor-like protein 5A"
FT                   /id="PRO_0000207468"
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         66..70
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         125..128
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         159
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   179 AA;  20724 MW;  527CF73C5DB049EA CRC64;
     MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS NVEEIVVNNT
     RFLMWDIGGQ ESLRPSWNTY YTNTEFVIVV VDSTDRERIS VTREELYKML AHEDLRKAGL
     LIFANKQDVK ECMTVAEISQ FLKLTSIKDH QWHIQACCAL TGEGLCQGLE WMMSRLKIR