ID   ARL5A_RAT               Reviewed;         179 AA.
AC   P51646; Q4V8N2;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=ADP-ribosylation factor-like protein 5A;
GN   Name=Arl5a; Synonyms=Arl5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Adipose tissue;
RX   PubMed=8765741; DOI=10.1016/0167-4781(96)00081-4;
RA   Breiner M., Schuermann A., Becker W., Joost H.-G.;
RT   "Cloning of a novel member (ARL5) of the ARF-family of Ras-related
RT   GTPases.";
RL   Biochim. Biophys. Acta 1308:1-6(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Lacks ADP-ribosylation enhancing activity.
CC   -!- TISSUE SPECIFICITY: Low amounts were found in most tissues examined
CC       with highest levels in brain, intestine and thymus.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; X78604; CAA55338.1; -; mRNA.
DR   EMBL; BC097294; AAH97294.1; -; mRNA.
DR   PIR; S72161; S72161.
DR   RefSeq; NP_446431.1; NM_053979.2.
DR   AlphaFoldDB; P51646; -.
DR   SMR; P51646; -.
DR   STRING; 10116.ENSRNOP00000009181; -.
DR   PhosphoSitePlus; P51646; -.
DR   PaxDb; P51646; -.
DR   Ensembl; ENSRNOT00000009181; ENSRNOP00000009181; ENSRNOG00000006839.
DR   GeneID; 117050; -.
DR   KEGG; rno:117050; -.
DR   UCSC; RGD:621327; rat.
DR   CTD; 26225; -.
DR   RGD; 621327; Arl5a.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00940000154714; -.
DR   HOGENOM; CLU_040729_9_1_1; -.
DR   InParanoid; P51646; -.
DR   OMA; IWRLFSH; -.
DR   OrthoDB; 1417432at2759; -.
DR   PhylomeDB; P51646; -.
DR   TreeFam; TF105465; -.
DR   PRO; PR:P51646; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000006839; Expressed in jejunum and 19 other tissues.
DR   Genevisible; P51646; RN.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:1903292; P:protein localization to Golgi membrane; ISO:RGD.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Lipoprotein; Myristate; Nucleotide-binding;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..179
FT                   /note="ADP-ribosylation factor-like protein 5A"
FT                   /id="PRO_0000207469"
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         66..70
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         125..128
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         159
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   179 AA;  20714 MW;  518CCBCF928CB9D5 CRC64;
     MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS NVEEIVVNNT
     RFLMWDIGGQ ESLRSSWNTY YTNTEFVIVV VDSTDRERIS VTREELYKML AHEDLRKAGL
     LIFANKQDVK ECMTVAEISQ FLKLTSIKDH QWHIQACCAL TGEGLCQGLE WMMSRLKIR