METJ_ACTP7
ID METJ_ACTP7 Reviewed; 105 AA.
AC B3H2Y8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Met repressor {ECO:0000255|HAMAP-Rule:MF_00744};
DE AltName: Full=Met regulon regulatory protein MetJ {ECO:0000255|HAMAP-Rule:MF_00744};
GN Name=metJ {ECO:0000255|HAMAP-Rule:MF_00744}; OrderedLocusNames=APP7_2006;
OS Actinobacillus pleuropneumoniae serotype 7 (strain AP76).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=537457;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP76;
RA Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N.,
RA Tegetmeyer H., Singh M., Gerlach G.F.;
RT "Genome and proteome analysis of A. pleuropneumoniae serotype 7.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC adenosylmethionine) represses the expression of the methionine regulon
CC and of enzymes involved in SAM synthesis. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
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DR EMBL; CP001091; ACE62658.1; -; Genomic_DNA.
DR RefSeq; WP_005599655.1; NC_010939.1.
DR AlphaFoldDB; B3H2Y8; -.
DR SMR; B3H2Y8; -.
DR EnsemblBacteria; ACE62658; ACE62658; APP7_2006.
DR GeneID; 66258712; -.
DR KEGG; apa:APP7_2006; -.
DR HOGENOM; CLU_142318_0_0_6; -.
DR OMA; KWNGEYI; -.
DR BioCyc; APLE537457:APP7_RS10485-MON; -.
DR Proteomes; UP000001226; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.140.10; -; 1.
DR HAMAP; MF_00744; MetJ; 1.
DR InterPro; IPR002084; Met_repressor_MetJ.
DR InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR InterPro; IPR010985; Ribbon_hlx_hlx.
DR Pfam; PF01340; MetJ; 1.
DR SUPFAM; SSF47598; SSF47598; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; DNA-binding; Methionine biosynthesis;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..105
FT /note="Met repressor"
FT /id="PRO_1000191207"
SQ SEQUENCE 105 AA; 12156 MW; AD364781F681BB67 CRC64;
MADWSGEYIS PYAEHGKKSE QVKKITVSIP IKVLEILTNE RTRRQIKNLR HATNSELLCE
AFLHAFTGQP LPTDDDLMKE RSDEIPEEAK AKMRELGIDP DNWQY