METJ_ACTSZ
ID METJ_ACTSZ Reviewed; 105 AA.
AC A6VLD8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Met repressor {ECO:0000255|HAMAP-Rule:MF_00744};
DE AltName: Full=Met regulon regulatory protein MetJ {ECO:0000255|HAMAP-Rule:MF_00744};
GN Name=metJ {ECO:0000255|HAMAP-Rule:MF_00744}; OrderedLocusNames=Asuc_0407;
OS Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 /
OS 130Z).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=339671;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z;
RX PubMed=21118570; DOI=10.1186/1471-2164-11-680;
RA McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A.,
RA Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L.,
RA Burkhart K.B., Harkins V., Vieille C.;
RT "A genomic perspective on the potential of Actinobacillus succinogenes for
RT industrial succinate production.";
RL BMC Genomics 11:680-680(2010).
CC -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC adenosylmethionine) represses the expression of the methionine regulon
CC and of enzymes involved in SAM synthesis. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000746; ABR73785.1; -; Genomic_DNA.
DR RefSeq; WP_012072170.1; NC_009655.1.
DR AlphaFoldDB; A6VLD8; -.
DR SMR; A6VLD8; -.
DR STRING; 339671.Asuc_0407; -.
DR EnsemblBacteria; ABR73785; ABR73785; Asuc_0407.
DR KEGG; asu:Asuc_0407; -.
DR eggNOG; COG3060; Bacteria.
DR HOGENOM; CLU_142318_0_0_6; -.
DR OMA; KWNGEYI; -.
DR OrthoDB; 1738030at2; -.
DR Proteomes; UP000001114; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.140.10; -; 1.
DR HAMAP; MF_00744; MetJ; 1.
DR InterPro; IPR002084; Met_repressor_MetJ.
DR InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR InterPro; IPR010985; Ribbon_hlx_hlx.
DR Pfam; PF01340; MetJ; 1.
DR SUPFAM; SSF47598; SSF47598; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; DNA-binding; Methionine biosynthesis;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..105
FT /note="Met repressor"
FT /id="PRO_1000072818"
SQ SEQUENCE 105 AA; 12280 MW; 8F44C0C4B79BAFFC CRC64;
MANWDGKYIS PYVEHGKKSE QVKKITVSIP IKVLEILTNE RTRRQIKNLR HATNSELLCE
AFLHAFTGQP LPTDSDLLKE RHDEIPEYAK QIMRESGVDP EEWEY