METJ_CROS8
ID METJ_CROS8 Reviewed; 105 AA.
AC A7ML79;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Met repressor {ECO:0000255|HAMAP-Rule:MF_00744};
DE AltName: Full=Met regulon regulatory protein MetJ {ECO:0000255|HAMAP-Rule:MF_00744};
GN Name=metJ {ECO:0000255|HAMAP-Rule:MF_00744}; OrderedLocusNames=ESA_03823;
OS Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Cronobacter.
OX NCBI_TaxID=290339;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-894;
RX PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA McClelland M., Forsythe S.J.;
RT "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT hybridization analysis with other Cronobacter species.";
RL PLoS ONE 5:E9556-E9556(2010).
CC -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC adenosylmethionine) represses the expression of the methionine regulon
CC and of enzymes involved in SAM synthesis. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
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DR EMBL; CP000783; ABU79009.1; -; Genomic_DNA.
DR RefSeq; WP_004385727.1; NC_009778.1.
DR AlphaFoldDB; A7ML79; -.
DR SMR; A7ML79; -.
DR EnsemblBacteria; ABU79009; ABU79009; ESA_03823.
DR GeneID; 45713705; -.
DR GeneID; 56732472; -.
DR GeneID; 60370789; -.
DR GeneID; 60764002; -.
DR KEGG; esa:ESA_03823; -.
DR HOGENOM; CLU_142318_0_0_6; -.
DR OMA; KWNGEYI; -.
DR OrthoDB; 1738030at2; -.
DR Proteomes; UP000000260; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00490; Met_repressor_MetJ; 1.
DR Gene3D; 1.10.140.10; -; 1.
DR HAMAP; MF_00744; MetJ; 1.
DR InterPro; IPR002084; Met_repressor_MetJ.
DR InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR InterPro; IPR010985; Ribbon_hlx_hlx.
DR Pfam; PF01340; MetJ; 1.
DR SUPFAM; SSF47598; SSF47598; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; DNA-binding; Methionine biosynthesis;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..105
FT /note="Met repressor"
FT /id="PRO_1000046488"
SQ SEQUENCE 105 AA; 12227 MW; 7D65093009886B2E CRC64;
MAEWNGEYIS PYAEHGKKSE QVKKITVSIP LKVLKILTDE RTRRQVNNLR HATNSELLCE
AFLHAFTGQP LPDDDDLRKE RSDEIPEEAK VIMREMGIDP DTWEY