ARL5C_HUMAN
ID ARL5C_HUMAN Reviewed; 179 AA.
AC A6NH57;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 4.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Putative ADP-ribosylation factor-like protein 5C;
DE AltName: Full=ADP-ribosylation factor-like protein 12;
GN Name=ARL5C; Synonyms=ARL12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
CC -!- FUNCTION: Binds and exchanges GTP and GDP. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; AC004408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45664.1; -.
DR RefSeq; NP_001137440.1; NM_001143968.1.
DR AlphaFoldDB; A6NH57; -.
DR SMR; A6NH57; -.
DR STRING; 9606.ENSP00000269586; -.
DR iPTMnet; A6NH57; -.
DR PhosphoSitePlus; A6NH57; -.
DR BioMuta; ARL5C; -.
DR MassIVE; A6NH57; -.
DR PaxDb; A6NH57; -.
DR PeptideAtlas; A6NH57; -.
DR PRIDE; A6NH57; -.
DR Antibodypedia; 57274; 41 antibodies from 12 providers.
DR DNASU; 390790; -.
DR Ensembl; ENST00000269586.12; ENSP00000269586.7; ENSG00000141748.13.
DR GeneID; 390790; -.
DR KEGG; hsa:390790; -.
DR MANE-Select; ENST00000269586.12; ENSP00000269586.7; NM_001143968.1; NP_001137440.1.
DR UCSC; uc010wea.3; human.
DR CTD; 390790; -.
DR DisGeNET; 390790; -.
DR GeneCards; ARL5C; -.
DR HGNC; HGNC:31111; ARL5C.
DR HPA; ENSG00000141748; Tissue enriched (lymphoid).
DR neXtProt; NX_A6NH57; -.
DR PharmGKB; PA134964408; -.
DR VEuPathDB; HostDB:ENSG00000141748; -.
DR eggNOG; KOG0070; Eukaryota.
DR GeneTree; ENSGT00940000163066; -.
DR HOGENOM; CLU_040729_9_1_1; -.
DR InParanoid; A6NH57; -.
DR OMA; LTKMMAV; -.
DR OrthoDB; 1417432at2759; -.
DR PhylomeDB; A6NH57; -.
DR TreeFam; TF105465; -.
DR PathwayCommons; A6NH57; -.
DR SignaLink; A6NH57; -.
DR BioGRID-ORCS; 390790; 11 hits in 1067 CRISPR screens.
DR GenomeRNAi; 390790; -.
DR Pharos; A6NH57; Tdark.
DR PRO; PR:A6NH57; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NH57; protein.
DR Bgee; ENSG00000141748; Expressed in body of pancreas and 89 other tissues.
DR ExpressionAtlas; A6NH57; baseline and differential.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:1903292; P:protein localization to Golgi membrane; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 3: Inferred from homology;
KW GTP-binding; Lipoprotein; Myristate; Nucleotide-binding;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..179
FT /note="Putative ADP-ribosylation factor-like protein 5C"
FT /id="PRO_0000332303"
FT BINDING 23..30
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 66..70
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 125..128
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 179 AA; 20591 MW; 2425EC4C595BEAED CRC64;
MGQLIAKLMS IFGNQEHTVI IVGLDNEGKT TILYRFLTNE VVHMCPTIGS NVEEIILPKT
HFFMWDIVRP EALSFIWNTY YSNTEFIILV IDSTDRDRLL TTREELYKML AHEALQDASV
LIFANKQDVK DSMRMVEISH FLTLSTIKDH SWHIQGCCAL TREGLPARLQ WMESQAAAN
