METJ_ECO8A
ID METJ_ECO8A Reviewed; 105 AA.
AC B7M6Z3;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Met repressor {ECO:0000255|HAMAP-Rule:MF_00744};
DE AltName: Full=Met regulon regulatory protein MetJ {ECO:0000255|HAMAP-Rule:MF_00744};
GN Name=metJ {ECO:0000255|HAMAP-Rule:MF_00744}; OrderedLocusNames=ECIAI1_4147;
OS Escherichia coli O8 (strain IAI1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585034;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAI1;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC adenosylmethionine) represses the expression of the methionine regulon
CC and of enzymes involved in SAM synthesis. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
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DR EMBL; CU928160; CAR00918.1; -; Genomic_DNA.
DR RefSeq; WP_000852812.1; NC_011741.1.
DR AlphaFoldDB; B7M6Z3; -.
DR SMR; B7M6Z3; -.
DR GeneID; 67417544; -.
DR KEGG; ecr:ECIAI1_4147; -.
DR HOGENOM; CLU_142318_0_0_6; -.
DR OMA; KWNGEYI; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00490; Met_repressor_MetJ; 1.
DR Gene3D; 1.10.140.10; -; 1.
DR HAMAP; MF_00744; MetJ; 1.
DR InterPro; IPR002084; Met_repressor_MetJ.
DR InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR InterPro; IPR010985; Ribbon_hlx_hlx.
DR Pfam; PF01340; MetJ; 1.
DR SUPFAM; SSF47598; SSF47598; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; DNA-binding; Methionine biosynthesis;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..105
FT /note="Met repressor"
FT /id="PRO_1000191213"
SQ SEQUENCE 105 AA; 12141 MW; 05B0F54918C697EF CRC64;
MAEWSGEYIS PYAEHGKKSE QVKKITVSIP LKVLKILTDE RTRRQVNNLR HATNSELLCE
AFLHAFTGQP LPDDADLRKE RSDEIPEAAK EIMREMGINP ETWEY