ID   METJ_HAEIN              Reviewed;         105 AA.
AC   P44618;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Met repressor;
DE   AltName: Full=Met regulon regulatory protein MetJ;
GN   Name=metJ; OrderedLocusNames=HI_0294;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC       adenosylmethionine) represses the expression of the methionine regulon
CC       and of enzymes involved in SAM synthesis. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC   -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000305}.
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DR   EMBL; L42023; AAC21958.1; -; Genomic_DNA.
DR   PIR; A64060; A64060.
DR   RefSeq; NP_438461.1; NC_000907.1.
DR   RefSeq; WP_005631186.1; NC_000907.1.
DR   AlphaFoldDB; P44618; -.
DR   SMR; P44618; -.
DR   STRING; 71421.HI_0294; -.
DR   EnsemblBacteria; AAC21958; AAC21958; HI_0294.
DR   KEGG; hin:HI_0294; -.
DR   PATRIC; fig|71421.8.peg.310; -.
DR   eggNOG; COG3060; Bacteria.
DR   HOGENOM; CLU_142318_0_0_6; -.
DR   OMA; KWNGEYI; -.
DR   PhylomeDB; P44618; -.
DR   BioCyc; HINF71421:G1GJ1-312-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00490; Met_repressor_MetJ; 1.
DR   Gene3D; 1.10.140.10; -; 1.
DR   HAMAP; MF_00744; MetJ; 1.
DR   InterPro; IPR002084; Met_repressor_MetJ.
DR   InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01340; MetJ; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; DNA-binding; Methionine biosynthesis;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..105
FT                   /note="Met repressor"
FT                   /id="PRO_0000198401"
SQ   SEQUENCE   105 AA;  12111 MW;  5F5C5AFE09F4F876 CRC64;
     MANWDGKYIS PYAEHGKKSE QVKKITVSIP IKVLEILTNE RTRRQLKSLR HATNSELLCE
     AFLHAFTGQP LPTDADLMKE RNDEIPEDAK VLMRELGVDP ESWEY