ARL5_CAEEL
ID ARL5_CAEEL Reviewed; 178 AA.
AC P34212;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=ADP-ribosylation factor-like protein 5;
GN Name=arl-5; ORFNames=ZK632.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24843160; DOI=10.1073/pnas.1400696111;
RA Szumowski S.C., Botts M.R., Popovich J.J., Smelkinson M.G., Troemel E.R.;
RT "The small GTPase RAB-11 directs polarized exocytosis of the intracellular
RT pathogen N. parisii for fecal-oral transmission from C. elegans.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:8215-8220(2014).
CC -!- FUNCTION: GTP-binding protein that may be involved in protein
CC trafficking; may modulate vesicle budding and uncoating within the
CC Golgi apparatus (By similarity). Plays a role in the shedding of
CC pathogen spores from intestinal cells (PubMed:24843160).
CC {ECO:0000250|UniProtKB:P40945, ECO:0000269|PubMed:24843160}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in disrupted
CC clearance of intracellular pathogen N.parisii from intestinal cells.
CC {ECO:0000269|PubMed:24843160}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; Z22181; CAA80185.1; -; Genomic_DNA.
DR PIR; S40940; S40940.
DR RefSeq; NP_499178.1; NM_066777.3.
DR AlphaFoldDB; P34212; -.
DR SMR; P34212; -.
DR STRING; 6239.ZK632.8; -.
DR EPD; P34212; -.
DR PaxDb; P34212; -.
DR PeptideAtlas; P34212; -.
DR EnsemblMetazoa; ZK632.8.1; ZK632.8.1; WBGene00000189.
DR GeneID; 176392; -.
DR UCSC; ZK632.8; c. elegans.
DR CTD; 176392; -.
DR WormBase; ZK632.8; CE00425; WBGene00000189; arl-5.
DR eggNOG; KOG0070; Eukaryota.
DR HOGENOM; CLU_040729_9_1_1; -.
DR InParanoid; P34212; -.
DR OMA; IMKEQLH; -.
DR OrthoDB; 1417432at2759; -.
DR PhylomeDB; P34212; -.
DR PRO; PR:P34212; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000189; Expressed in embryo and 3 other tissues.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:WormBase.
DR GO; GO:1903292; P:protein localization to Golgi membrane; IBA:GO_Central.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR024156; Small_GTPase_ARF.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR11711; PTHR11711; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 3: Inferred from homology;
KW ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Myristate;
KW Nucleotide-binding; Protein transport; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..178
FT /note="ADP-ribosylation factor-like protein 5"
FT /id="PRO_0000207408"
FT BINDING 24..31
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 67..71
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 126..129
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 178 AA; 20033 MW; E7CF7668C1A8D4E1 CRC64;
MGLIMAKLFQ SWWIGKKYKI IVVGLDNAGK TTILYNYVTK DQVETKPTIG SNVEEVSYRN
LDFVIWDIGG QESLRKSWST YYVQTDVVIV VIDSSDTTRI PIMKEQLHNM LQHEDLARAH
ILVLANKQDL PGAMNPAEVS TQLGLQTLRG ARKWQINGCC AVKGEGLPEA LEWIANNL
