ID   METJ_HAMD5              Reviewed;         105 AA.
AC   C4K6P9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Met repressor {ECO:0000255|HAMAP-Rule:MF_00744};
DE   AltName: Full=Met regulon regulatory protein MetJ {ECO:0000255|HAMAP-Rule:MF_00744};
GN   Name=metJ {ECO:0000255|HAMAP-Rule:MF_00744}; OrderedLocusNames=HDEF_1630;
OS   Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; aphid secondary symbionts; Candidatus Hamiltonella.
OX   NCBI_TaxID=572265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5AT;
RX   PubMed=19451630; DOI=10.1073/pnas.0900194106;
RA   Degnan P.H., Yu Y., Sisneros N., Wing R.A., Moran N.A.;
RT   "Hamiltonella defensa, genome evolution of protective bacterial
RT   endosymbiont from pathogenic ancestors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:9063-9068(2009).
CC   -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC       adenosylmethionine) represses the expression of the methionine regulon
CC       and of enzymes involved in SAM synthesis. {ECO:0000255|HAMAP-
CC       Rule:MF_00744}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00744}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00744}.
CC   -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC   -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000255|HAMAP-
CC       Rule:MF_00744}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001277; ACQ68242.1; -; Genomic_DNA.
DR   RefSeq; WP_015874009.1; NC_012751.1.
DR   AlphaFoldDB; C4K6P9; -.
DR   SMR; C4K6P9; -.
DR   STRING; 572265.HDEF_1630; -.
DR   EnsemblBacteria; ACQ68242; ACQ68242; HDEF_1630.
DR   GeneID; 66261238; -.
DR   KEGG; hde:HDEF_1630; -.
DR   eggNOG; COG3060; Bacteria.
DR   HOGENOM; CLU_142318_0_0_6; -.
DR   OMA; KWNGEYI; -.
DR   Proteomes; UP000002334; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.140.10; -; 1.
DR   HAMAP; MF_00744; MetJ; 1.
DR   InterPro; IPR002084; Met_repressor_MetJ.
DR   InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01340; MetJ; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; DNA-binding; Methionine biosynthesis;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..105
FT                   /note="Met repressor"
FT                   /id="PRO_1000212835"
SQ   SEQUENCE   105 AA;  12210 MW;  06A3C1A50ADC513E CRC64;
     MAKWNGQYIS PYAEQGKKSE QVKKITVCIP TKVLKILTDE RTRRQINNLR HATNSELLCE
     AFLHAFTGQP LPNDDDLRKE RNDEIPQAAR ILMRDLGINP DTWEY