ID   METJ_SALTY              Reviewed;         105 AA.
AC   P06203;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Met repressor;
DE   AltName: Full=Met regulon regulatory protein MetJ;
GN   Name=metJ; OrderedLocusNames=STM4099;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=2987805; DOI=10.1093/nar/13.3.673;
RA   Urbanowski M.L., Stauffer G.V.;
RT   "Nucleotide sequence and biochemical characterization of the metJ gene from
RT   Salmonella typhimurium LT2.";
RL   Nucleic Acids Res. 13:673-685(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC       adenosylmethionine) represses the expression of the methionine regulon
CC       and of enzymes involved in SAM synthesis. It is also autoregulated (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC   -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000305}.
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DR   EMBL; X01961; CAA25997.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22939.1; -; Genomic_DNA.
DR   PIR; A23081; A23081.
DR   RefSeq; NP_462980.1; NC_003197.2.
DR   RefSeq; WP_000852810.1; NC_003197.2.
DR   AlphaFoldDB; P06203; -.
DR   SMR; P06203; -.
DR   STRING; 99287.STM4099; -.
DR   PaxDb; P06203; -.
DR   EnsemblBacteria; AAL22939; AAL22939; STM4099.
DR   GeneID; 1255626; -.
DR   KEGG; stm:STM4099; -.
DR   PATRIC; fig|99287.12.peg.4321; -.
DR   HOGENOM; CLU_142318_0_0_6; -.
DR   OMA; KWNGEYI; -.
DR   PhylomeDB; P06203; -.
DR   BioCyc; SENT99287:STM4099-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00490; Met_repressor_MetJ; 1.
DR   Gene3D; 1.10.140.10; -; 1.
DR   HAMAP; MF_00744; MetJ; 1.
DR   InterPro; IPR002084; Met_repressor_MetJ.
DR   InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01340; MetJ; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; DNA-binding; Methionine biosynthesis;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..105
FT                   /note="Met repressor"
FT                   /id="PRO_0000198405"
SQ   SEQUENCE   105 AA;  12124 MW;  05B1B04918C6990F CRC64;
     MAEWSGEYIS PYAEHGKKSE QVKKITVSIP LKVLKILTDE RTRRQVNNLR HATNSELLCE
     AFLHAFTGQP LPDDADLRKE RSDEIPEAAK EIMRELGIDP ETWEY