METJ_YERPB
ID METJ_YERPB Reviewed; 105 AA.
AC B2JZD3;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Met repressor {ECO:0000255|HAMAP-Rule:MF_00744};
DE AltName: Full=Met regulon regulatory protein MetJ {ECO:0000255|HAMAP-Rule:MF_00744};
GN Name=metJ {ECO:0000255|HAMAP-Rule:MF_00744}; OrderedLocusNames=YPTS_0107;
OS Yersinia pseudotuberculosis serotype IB (strain PB1/+).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=502801;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB1/+;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT "Complete sequence of Yersinia pseudotuberculosis PB1/+.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC adenosylmethionine) represses the expression of the methionine regulon
CC and of enzymes involved in SAM synthesis. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00744}.
CC -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000255|HAMAP-
CC Rule:MF_00744}.
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DR EMBL; CP001048; ACC87106.1; -; Genomic_DNA.
DR RefSeq; WP_004392248.1; NZ_CP009780.1.
DR AlphaFoldDB; B2JZD3; -.
DR SMR; B2JZD3; -.
DR GeneID; 61906188; -.
DR GeneID; 67421892; -.
DR KEGG; ypb:YPTS_0107; -.
DR PATRIC; fig|502801.10.peg.3786; -.
DR OMA; KWNGEYI; -.
DR BioCyc; YPSE502801:YPTS_RS00545-MON; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd00490; Met_repressor_MetJ; 1.
DR Gene3D; 1.10.140.10; -; 1.
DR HAMAP; MF_00744; MetJ; 1.
DR InterPro; IPR002084; Met_repressor_MetJ.
DR InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR InterPro; IPR010985; Ribbon_hlx_hlx.
DR Pfam; PF01340; MetJ; 1.
DR SUPFAM; SSF47598; SSF47598; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Cytoplasm; DNA-binding; Methionine biosynthesis;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..105
FT /note="Met repressor"
FT /id="PRO_1000133224"
SQ SEQUENCE 105 AA; 12150 MW; B97642A8320F881F CRC64;
MAEWNGEYVS PYAEHGKKSE QVKKITVSIP LKVLKILTDE RTRRQVNNLR HATNSELLCE
AFLHAFTGQP LPNDEDLRKE RSDEIPEAAK ILMRELGVDP DTWEY