ID   ARL8A_CHICK             Reviewed;         186 AA.
AC   Q5ZKQ8;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=ADP-ribosylation factor-like protein 8A;
GN   Name=ARL8A; ORFNames=RCJMB04_9k9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Plays a role in lysosome motility. In neurons, mediates the
CC       anterograde axonal long-range transport of presynaptic lysosome-related
CC       vesicles required for presynaptic biogenesis and synaptic function (By
CC       similarity). May play a role in chromosome segregation (By similarity).
CC       {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000250|UniProtKB:Q9NVJ2}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane
CC       {ECO:0000250|UniProtKB:Q9NVJ2}. Lysosome membrane
CC       {ECO:0000250|UniProtKB:Q9CQW2}. Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000250|UniProtKB:Q9NVJ2}. Cell projection, axon
CC       {ECO:0000250|UniProtKB:Q9CQW2}. Synapse {ECO:0000250|UniProtKB:Q9CQW2}.
CC       Note=Localizes with microtubules at the spindle mid-zone during
CC       mitosis. {ECO:0000250|UniProtKB:Q9NVJ2}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; AJ720026; CAG31685.1; -; mRNA.
DR   RefSeq; NP_001012886.1; NM_001012868.2.
DR   AlphaFoldDB; Q5ZKQ8; -.
DR   SMR; Q5ZKQ8; -.
DR   STRING; 9031.ENSGALP00000040104; -.
DR   PaxDb; Q5ZKQ8; -.
DR   PRIDE; Q5ZKQ8; -.
DR   Ensembl; ENSGALT00000040899; ENSGALP00000040104; ENSGALG00000000606.
DR   GeneID; 421175; -.
DR   KEGG; gga:421175; -.
DR   CTD; 127829; -.
DR   VEuPathDB; HostDB:geneid_421175; -.
DR   eggNOG; KOG0075; Eukaryota.
DR   GeneTree; ENSGT00940000159657; -.
DR   InParanoid; Q5ZKQ8; -.
DR   OMA; KIDIQPH; -.
DR   OrthoDB; 1123043at2759; -.
DR   PhylomeDB; Q5ZKQ8; -.
DR   PRO; PR:Q5ZKQ8; -.
DR   Proteomes; UP000000539; Chromosome 26.
DR   Bgee; ENSGALG00000000606; Expressed in brain and 13 other tissues.
DR   ExpressionAtlas; Q5ZKQ8; baseline and differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008089; P:anterograde axonal transport; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd04159; Arl10_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR044154; Arl8a/8b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cell projection; Chromosome partition;
KW   Cytoplasm; Cytoskeleton; Endosome; GTP-binding; Lysosome; Membrane;
KW   Mitosis; Nucleotide-binding; Protein transport; Reference proteome;
KW   Synapse; Transport.
FT   CHAIN           1..186
FT                   /note="ADP-ribosylation factor-like protein 8A"
FT                   /id="PRO_0000232918"
FT   INTRAMEM        1..19
FT                   /note="Note=Mediates targeting to membranes"
FT                   /evidence="ECO:0000250"
FT   BINDING         29..35
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         130..133
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   186 AA;  21444 MW;  607B8BB7B32E6E75 CRC64;
     MLALFNKLLD WFRALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI PTVGFNMRKI
     TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD QEKIEASKNE LHNLLDKPQL
     QGIPVLVLGN KRDLPGALDE KELIEKMNLS AIQDREICCY SISCKEKDNI DITLQWLIQH
     SKSRRS