ID   ARL8A_XENTR             Reviewed;         186 AA.
AC   Q6P8C8;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=ADP-ribosylation factor-like protein 8A;
DE   AltName: Full=ADP-ribosylation factor-like protein 10B;
GN   Name=arl8a; Synonyms=arl10b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in lysosomes motility. Alternatively, may
CC       play a role in chromosome segregation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}. Lysosome
CC       membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; BC061301; AAH61301.1; -; mRNA.
DR   RefSeq; NP_988990.1; NM_203659.1.
DR   AlphaFoldDB; Q6P8C8; -.
DR   SMR; Q6P8C8; -.
DR   STRING; 8364.ENSXETP00000001981; -.
DR   PaxDb; Q6P8C8; -.
DR   DNASU; 394587; -.
DR   Ensembl; ENSXETT00000001981; ENSXETP00000001981; ENSXETG00000000910.
DR   GeneID; 394587; -.
DR   KEGG; xtr:394587; -.
DR   CTD; 127829; -.
DR   Xenbase; XB-GENE-866659; arl8a.
DR   eggNOG; KOG0075; Eukaryota.
DR   HOGENOM; CLU_040729_10_0_1; -.
DR   InParanoid; Q6P8C8; -.
DR   OrthoDB; 1123043at2759; -.
DR   PhylomeDB; Q6P8C8; -.
DR   Reactome; R-XTR-6798695; Neutrophil degranulation.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000910; Expressed in brain and 7 other tissues.
DR   ExpressionAtlas; Q6P8C8; baseline.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008089; P:anterograde axonal transport; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   CDD; cd04159; Arl10_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR044154; Arl8a/8b.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Chromosome partition; Endosome; GTP-binding;
KW   Lysosome; Membrane; Mitosis; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..186
FT                   /note="ADP-ribosylation factor-like protein 8A"
FT                   /id="PRO_0000232919"
FT   INTRAMEM        1..19
FT                   /note="Note=Mediates targeting to membranes"
FT                   /evidence="ECO:0000250"
FT   BINDING         29..35
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         71..75
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         130..133
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   186 AA;  21404 MW;  46FF6EB9333859A7 CRC64;
     MLALFNKLLD WFKALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI PTVGFNMRKI
     TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD QDKIEASKNE LHNLLDKAQL
     QGIPVLVLGN KRDIPGALDE KELIERMNLS AIQDREICCY SISCKEKDNI DITLQWLIQH
     SKSRRS