ID   METK_AERPE              Reviewed;         406 AA.
AC   Q9YBK2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=S-adenosylmethionine synthase;
DE            Short=AdoMet synthase;
DE            EC=2.5.1.6;
DE   AltName: Full=Methionine adenosyltransferase;
GN   Name=mat; OrderedLocusNames=APE_1596;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Catalyzes the formation of S-adenosylmethionine from
CC       methionine and ATP. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + L-methionine = diphosphate + phosphate + S-
CC         adenosyl-L-methionine; Xref=Rhea:RHEA:21080, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57844, ChEBI:CHEBI:59789; EC=2.5.1.6;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis;
CC       S-adenosyl-L-methionine from L-methionine: step 1/1.
CC   -!- SIMILARITY: Belongs to the AdoMet synthase 2 family. {ECO:0000305}.
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DR   EMBL; BA000002; BAA80596.1; -; Genomic_DNA.
DR   PIR; G72538; G72538.
DR   AlphaFoldDB; Q9YBK2; -.
DR   SMR; Q9YBK2; -.
DR   STRING; 272557.APE_1596; -.
DR   EnsemblBacteria; BAA80596; BAA80596; APE_1596.
DR   KEGG; ape:APE_1596; -.
DR   PATRIC; fig|272557.25.peg.1080; -.
DR   eggNOG; arCOG01678; Archaea.
DR   OMA; IGHPDSI; -.
DR   UniPathway; UPA00315; UER00080.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004478; F:methionine adenosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.300.280; -; 2.
DR   HAMAP; MF_00136; S_AdoMet_synth2; 1.
DR   InterPro; IPR027790; AdoMet_synthase_2_family.
DR   InterPro; IPR042544; AdoMet_synthase_3.
DR   InterPro; IPR002795; S-AdoMet_synthetase_arc.
DR   PANTHER; PTHR36697; PTHR36697; 1.
DR   Pfam; PF01941; AdoMet_Synthase; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Magnesium; Nucleotide-binding; One-carbon metabolism;
KW   Reference proteome; Transferase.
FT   CHAIN           1..406
FT                   /note="S-adenosylmethionine synthase"
FT                   /id="PRO_0000150024"
FT   BINDING         140..145
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   406 AA;  44235 MW;  F6EDAB5BC5544B73 CRC64;
     MARRIVVESY PYPRVEDLQV ELVERKGLGH PDTICDAAAE AVSRELSKYY LERFGKILHH
     NVDKVLLVGG QAAPRLGGGE VLQPIYILVS GRVTTEVRTG GGVESVPVGP IILRAVKNYI
     RENFRFLDPE EHVIVDYRVG RGSVDLVGIF EAEDKVPLAN DTSIGSGHAP LSTLERLVLE
     TERILNSRET KERLPAVGED VKVMGVRDGK SITLTVAMAV VSSQVGSVSD YLAVKEEAES
     LILDLASRIA PDYDVRVNIN TGDIPEKKIL YLTVTGTSAE HGDDGATGRG NRVNGLITPM
     RPMSMEAAAG KNPVNHVGKI YNVVANEMAA LIHREVKGVE EVYVKLVSQI GKPIDRPRIV
     DVKVRMEGGR EVTADAKREI EAIANSVLDG ITGYTEKLVR GDITVY