ARL8D_ARATH
ID ARL8D_ARATH Reviewed; 176 AA.
AC F4IZ82; Q9M2X2;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=ADP-ribosylation factor-like protein 8d {ECO:0000303|PubMed:22174675};
DE Short=AtARL8d {ECO:0000303|PubMed:22174675};
DE AltName: Full=ADP-ribosylation factor-like A1B {ECO:0000303|PubMed:12644670};
DE Short=AtARLA1B {ECO:0000303|PubMed:12644670};
GN Name=ARL8D {ECO:0000303|PubMed:22174675};
GN Synonyms=ARLA1B {ECO:0000303|PubMed:12644670};
GN OrderedLocusNames=At3g49860 {ECO:0000312|Araport:AT3G49860};
GN ORFNames=T16K5.210 {ECO:0000312|EMBL:CAB66924.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12644670; DOI=10.1104/pp.013052;
RA Vernoud V., Horton A.C., Yang Z., Nielsen E.;
RT "Analysis of the small GTPase gene superfamily of Arabidopsis.";
RL Plant Physiol. 131:1191-1208(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=15723828; DOI=10.1093/jxb/eri099;
RA Gebbie L.K., Burn J.E., Hocart C.H., Williamson R.E.;
RT "Genes encoding ADP-ribosylation factors in Arabidopsis thaliana; genome
RT analysis and antisense suppression.";
RL J. Exp. Bot. 56:1079-1091(2005).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=22174675; DOI=10.1371/journal.ppat.1002409;
RA Nishikiori M., Mori M., Dohi K., Okamura H., Katoh E., Naito S., Meshi T.,
RA Ishikawa M.;
RT "A host small GTP-binding protein ARL8 plays crucial roles in tobamovirus
RT RNA replication.";
RL PLoS Pathog. 7:E1002409-E1002409(2011).
CC -!- FUNCTION: May play a role in lysosome motility. May play a role in
CC chromosome segregation. {ECO:0000250|UniProtKB:Q9NVJ2}.
CC -!- SUBUNIT: Interacts with tubulin. {ECO:0000250|UniProtKB:Q9NVJ2}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000250|UniProtKB:Q9NVJ2}. Lysosome membrane
CC {ECO:0000250|UniProtKB:Q9NVJ2}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250|UniProtKB:Q9NVJ2}. Note=Localizes with microtubules at the
CC spindle mid-zone during mitosis. {ECO:0000250|UniProtKB:Q9NVJ2}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB66924.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL132965; CAB66924.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002686; AEE78599.1; -; Genomic_DNA.
DR PIR; T46052; T46052.
DR RefSeq; NP_190555.2; NM_114846.4.
DR AlphaFoldDB; F4IZ82; -.
DR SMR; F4IZ82; -.
DR STRING; 3702.AT3G49860.1; -.
DR PaxDb; F4IZ82; -.
DR PRIDE; F4IZ82; -.
DR ProteomicsDB; 240615; -.
DR EnsemblPlants; AT3G49860.1; AT3G49860.1; AT3G49860.
DR GeneID; 824148; -.
DR Gramene; AT3G49860.1; AT3G49860.1; AT3G49860.
DR KEGG; ath:AT3G49860; -.
DR Araport; AT3G49860; -.
DR TAIR; locus:2097340; AT3G49860.
DR eggNOG; KOG0075; Eukaryota.
DR HOGENOM; CLU_040729_10_3_1; -.
DR InParanoid; F4IZ82; -.
DR OMA; KCIAFVF; -.
DR OrthoDB; 1123043at2759; -.
DR PRO; PR:F4IZ82; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4IZ82; baseline and differential.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; ISS:TAIR.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IGI:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR CDD; cd04159; Arl10_like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR044154; Arl8a/8b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Chromosome partition; Cytoplasm; Cytoskeleton;
KW Endosome; GTP-binding; Lysosome; Membrane; Mitosis; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..176
FT /note="ADP-ribosylation factor-like protein 8d"
FT /id="PRO_0000438006"
FT BINDING 21..26
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62330"
FT BINDING 40..43
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62330"
FT BINDING 62..66
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62330"
FT BINDING 121..124
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P62330"
SQ SEQUENCE 176 AA; 19489 MW; 6838868665977A87 CRC64;
MTLQPNLQAK EMELSLVGLQ NSGKTSLVNV VATGEYSEDM IPTVGFNMRK VTKENVAIRL
WDLGGQPRFR CMWERYCRAV SMIVYVVDAA DTENLSVSRS ELHDLLSNAS LIGIPLLVLG
NKIDIHGALS KEALTEEMGL SSVTSREVCC LMISCKNPTT IDQLTDWLVN HSKSKN
