ARL8_DICDI
ID ARL8_DICDI Reviewed; 185 AA.
AC Q54R04;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=ADP-ribosylation factor-like protein 8;
GN Name=arl8; Synonyms=arlE; ORFNames=DDB_G0283525;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000055; EAL65747.1; -; Genomic_DNA.
DR RefSeq; XP_639087.1; XM_633995.1.
DR AlphaFoldDB; Q54R04; -.
DR SMR; Q54R04; -.
DR STRING; 44689.DDB0229376; -.
DR PaxDb; Q54R04; -.
DR EnsemblProtists; EAL65747; EAL65747; DDB_G0283525.
DR GeneID; 8624111; -.
DR KEGG; ddi:DDB_G0283525; -.
DR dictyBase; DDB_G0283525; arl8.
DR eggNOG; KOG0075; Eukaryota.
DR HOGENOM; CLU_040729_10_1_1; -.
DR InParanoid; Q54R04; -.
DR OMA; GREVSCY; -.
DR PhylomeDB; Q54R04; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR PRO; PR:Q54R04; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR CDD; cd04159; Arl10_like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR044154; Arl8a/8b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 3: Inferred from homology;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..185
FT /note="ADP-ribosylation factor-like protein 8"
FT /id="PRO_0000328149"
FT BINDING 28..34
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 70..74
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 129..132
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 185 AA; 20771 MW; 2721A4FFA21A2FF2 CRC64;
MNFFESIINF FKSLFWKQEM ELTLVGLQGS GKTTLVNVIS NGGFIEDTIP TIGFNMKKVT
KGNVTIKLWD IGGQPRFRSM WERYCRGVNA IVFVVDSADR EKFEQSKQAL QDLINKPPLA
KIPLLVVANK NDLPNSAGVD EMIQNLDLRG IVGREVCCYS ISAKNSVNID ITLDWLIKHS
SSVKN