ARL9_HUMAN
ID ARL9_HUMAN Reviewed; 187 AA.
AC Q6T311;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=ADP-ribosylation factor-like protein 9;
GN Name=ARL9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15033445; DOI=10.1016/j.bbrc.2004.02.091;
RA Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M.,
RA Verjovski-Almeida S., Reis E.M.;
RT "Rasl11a, member of a novel small monomeric GTPase gene family, is
RT differentially expressed in prostate tumors.";
RL Biochem. Biophys. Res. Commun. 316:618-627(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-98 (ISOFORM 2).
RX PubMed=16341674; DOI=10.1007/s00335-005-0075-2;
RA Oh J.H., Yang J.O., Hahn Y., Kim M.R., Byun S.S., Jeon Y.J., Kim J.M.,
RA Song K.S., Noh S.M., Kim S., Yoo H.S., Kim Y.S., Kim N.S.;
RT "Transcriptome analysis of human gastric cancer.";
RL Mamm. Genome 16:942-954(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6T311-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6T311-2; Sequence=VSP_055413;
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; AY439003; AAS07576.1; -; mRNA.
DR EMBL; AC114766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC108215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BM854066; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59474.1; -. [Q6T311-2]
DR RefSeq; NP_996802.1; NM_206919.1. [Q6T311-2]
DR RefSeq; XP_005265777.1; XM_005265720.3. [Q6T311-2]
DR RefSeq; XP_006714099.1; XM_006714036.3. [Q6T311-2]
DR AlphaFoldDB; Q6T311; -.
DR SMR; Q6T311; -.
DR BioGRID; 126341; 15.
DR STRING; 9606.ENSP00000353210; -.
DR iPTMnet; Q6T311; -.
DR PhosphoSitePlus; Q6T311; -.
DR BioMuta; ARL9; -.
DR DMDM; 74749334; -.
DR MassIVE; Q6T311; -.
DR MaxQB; Q6T311; -.
DR PaxDb; Q6T311; -.
DR PeptideAtlas; Q6T311; -.
DR PRIDE; Q6T311; -.
DR ProteomicsDB; 67365; -. [Q6T311-1]
DR TopDownProteomics; Q6T311-1; -. [Q6T311-1]
DR Antibodypedia; 24040; 26 antibodies from 12 providers.
DR DNASU; 132946; -.
DR Ensembl; ENST00000360096.3; ENSP00000353210.2; ENSG00000196503.5. [Q6T311-2]
DR GeneID; 132946; -.
DR KEGG; hsa:132946; -.
DR UCSC; uc003hby.2; human. [Q6T311-1]
DR CTD; 132946; -.
DR DisGeNET; 132946; -.
DR GeneCards; ARL9; -.
DR HGNC; HGNC:23592; ARL9.
DR HPA; ENSG00000196503; Tissue enhanced (testis).
DR MIM; 612405; gene.
DR neXtProt; NX_Q6T311; -.
DR OpenTargets; ENSG00000196503; -.
DR PharmGKB; PA134987258; -.
DR VEuPathDB; HostDB:ENSG00000196503; -.
DR eggNOG; KOG0070; Eukaryota.
DR GeneTree; ENSGT00940000159397; -.
DR HOGENOM; CLU_2014454_0_0_1; -.
DR InParanoid; Q6T311; -.
DR PhylomeDB; Q6T311; -.
DR TreeFam; TF105469; -.
DR BRENDA; 3.6.5.2; 2681.
DR PathwayCommons; Q6T311; -.
DR SignaLink; Q6T311; -.
DR BioGRID-ORCS; 132946; 4 hits in 1058 CRISPR screens.
DR ChiTaRS; ARL9; human.
DR GenomeRNAi; 132946; -.
DR Pharos; Q6T311; Tdark.
DR PRO; PR:Q6T311; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6T311; protein.
DR Bgee; ENSG00000196503; Expressed in cortical plate and 98 other tissues.
DR ExpressionAtlas; Q6T311; baseline and differential.
DR Genevisible; Q6T311; HS.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..187
FT /note="ADP-ribosylation factor-like protein 9"
FT /id="PRO_0000207475"
FT BINDING 25..32
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 69..73
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 126..129
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..64
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16341674"
FT /id="VSP_055413"
SQ SEQUENCE 187 AA; 20755 MW; 620432EC357013EA CRC64;
MRPTWKALSH PAWPEEKNKQ ILVLGLDGAG KTSVLHSLAS NRVQHSVAPT QGFHAVCINT
EDSQMEFLEI GGSKPFRSYW EMYLSKGLLL IFVVDSADHS RLPEAKKYLH QLIAANPVLP
LVVFANKQDL EAAYHITDIH EALALSEVGN DRKMFLFGTY LTKNGSEIPS TMQDAKDLIA
QLAADVQ
