ID   ARLC_MAIZE              Reviewed;         610 AA.
AC   P13526;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Anthocyanin regulatory Lc protein;
GN   Name=LC;
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2674946; DOI=10.1073/pnas.86.18.7092;
RA   Ludwig S.R., Habera L.F., Dellaporta S.L., Wessler S.R.;
RT   "Lc, a member of the maize R gene family responsible for tissue-specific
RT   anthocyanin production, encodes a protein similar to transcriptional
RT   activators and contains the myc-homology region.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:7092-7096(1989).
CC   -!- FUNCTION: Putative transcriptional activator. Control tissue-specific
CC       synthesis of anthocyanin pigments in various parts of the maize plant.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- INTERACTION:
CC       P13526; A6YRS1: rif1; NbExp=3; IntAct=EBI-15666062, EBI-15666028;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- SIMILARITY: Belongs to the bHLH protein family.
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DR   EMBL; M26227; AAA33504.1; -; mRNA.
DR   PIR; A41388; A41388.
DR   RefSeq; NP_001105339.1; NM_001111869.1.
DR   AlphaFoldDB; P13526; -.
DR   SMR; P13526; -.
DR   DIP; DIP-46214N; -.
DR   IntAct; P13526; 1.
DR   PaxDb; P13526; -.
DR   GeneID; 100126972; -.
DR   MaizeGDB; 65390; -.
DR   Proteomes; UP000007305; Unplaced.
DR   ExpressionAtlas; P13526; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR025610; MYC/MYB_N.
DR   Pfam; PF14215; bHLH-MYC_N; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..610
FT                   /note="Anthocyanin regulatory Lc protein"
FT                   /id="PRO_0000127124"
FT   DOMAIN          412..461
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          402..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          468..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..521
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   610 AA;  66272 MW;  B691DB48B94AC757 CRC64;
     MALSASRVQQ AEELLQRPAE RQLMRSQLAA AARSINWSYA LFWSISDTQP GVLTWTDGFY
     NGEVKTRKIS NSVELTSDQL VMQRSDQLRE LYEALLSGEG DRRAAPARPA GSLSPEDLGD
     TEWYYVVSMT YAFRPGQGLP GRSFASDEHV WLCNAHLAGS KAFPRALLAK SASIQSILCI
     PVMGGVLELG TTDTVPEAPD LVSRATAAFW EPQCPSSSPS GRANETGEAA ADDGTFAFEE
     LDHNNGMDDI EAMTAAGGHG QEEELRLREA EALSDDASLE HITKEIEEFY SLCDEMDLQA
     LPLPLEDGWT VDASNFEVPC SSPQPAPPPV DRATANVAAD ASRAPVYGSR ATSFMAWTRS
     SQQSSCSDDA APAAVVPAIE EPQRLLKKVV AGGGAWESCG GATGAAQEMS GTGTKNHVMS
     ERKRREKLNE MFLVLKSLLP SIHRVNKASI LAETIAYLKE LQRRVQELES SREPASRPSE
     TTTRLITRPS RGNNESVRKE VCAGSKRKSP ELGRDDVERP PVLTMDAGTS NVTVTVSDKD
     VLLEVQCRWE ELLMTRVFDA IKSLHLDVLS VQASAPDGFM GLKIRAQFAG SGAVVPWMIS
     EALRKAIGKR