ARLR_STAAB
ID ARLR_STAAB Reviewed; 219 AA.
AC Q2YY03;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Response regulator ArlR;
GN Name=arlR; OrderedLocusNames=SAB1271c;
OS Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=273036;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bovine RF122 / ET3-1;
RX PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT "Molecular correlates of host specialization in Staphylococcus aureus.";
RL PLoS ONE 2:E1120-E1120(2007).
CC -!- FUNCTION: Member of the two-component regulatory system ArlS/ArlR
CC involved in the regulation of adhesion, autolysis, multidrug resistance
CC and virulence. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated by ArlS. {ECO:0000250}.
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DR EMBL; AJ938182; CAI80960.1; -; Genomic_DNA.
DR RefSeq; WP_000192137.1; NC_007622.1.
DR AlphaFoldDB; Q2YY03; -.
DR SMR; Q2YY03; -.
DR KEGG; sab:SAB1271c; -.
DR HOGENOM; CLU_000445_30_1_9; -.
DR OMA; NIHGEGF; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Repressor;
KW Transcription; Transcription regulation; Two-component regulatory system;
KW Virulence.
FT CHAIN 1..219
FT /note="Response regulator ArlR"
FT /id="PRO_0000293441"
FT DOMAIN 3..116
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 122..219
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 52
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 219 AA; 25498 MW; 721458C704EBFDF7 CRC64;
MTQILIVEDE QNLARFLELE LTHENYNVDT EYDGQDGLDK ALSHYYDLII LDLMLPSING
LEICRKIRQQ QSTPIIIITA KSDTYDKVAG LDYGADDYIV KPFDIEELLA RIRAILRRQP
QKDIIDVNGI TIDKNAFKVT VNGAEIELTK TEYDLLYLLA ENKNHVMQRE QILNHVWGYN
SEVETNVVDV YIRYLRNKLK PYDRDKMIET VRGVGYVIR