ID   ARLX_DICDI              Reviewed;         186 AA.
AC   Q1ZXA5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=ADP-ribosylation factor-like protein DDB_G0292332;
GN   ORFNames=DDB_G0292332;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Binds and exchanges GTP and GDP. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000189; EAS66811.1; -; Genomic_DNA.
DR   RefSeq; XP_001134494.1; XM_001134494.1.
DR   AlphaFoldDB; Q1ZXA5; -.
DR   SMR; Q1ZXA5; -.
DR   STRING; 44689.DDB0233231; -.
DR   PaxDb; Q1ZXA5; -.
DR   EnsemblProtists; EAS66811; EAS66811; DDB_G0292332.
DR   GeneID; 8628628; -.
DR   KEGG; ddi:DDB_G0292332; -.
DR   dictyBase; DDB_G0292332; -.
DR   eggNOG; KOG0071; Eukaryota.
DR   HOGENOM; CLU_1457011_0_0_1; -.
DR   InParanoid; Q1ZXA5; -.
DR   OMA; KETNRIC; -.
DR   PhylomeDB; Q1ZXA5; -.
DR   Reactome; R-DDI-1660514; Synthesis of PIPs at the Golgi membrane.
DR   Reactome; R-DDI-5620916; VxPx cargo-targeting to cilium.
DR   Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-DDI-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:Q1ZXA5; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:1903292; P:protein localization to Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..186
FT                   /note="ADP-ribosylation factor-like protein DDB_G0292332"
FT                   /id="PRO_0000367251"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         78..82
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         138..141
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   186 AA;  21595 MW;  E4FA83D92A6DEF0F CRC64;
     MDFIISFIKN LFGFLTIKKV MILGVENVGK TTLLYNIYKF YSENITTTTL SSLPIPIPTN
     GFNVESIVIE QVKFDIWDIG GKETNRICYR HYLTSEIDSI IFVFDSSDIN SLEESKKEYQ
     YLKNQISLKN VPFLLVANKQ DLKQQTIEID EILKTYFDKS SINETILMSQ NNNDDLIKCI
     NWIFSN