ARLY1_ALKCK
ID ARLY1_ALKCK Reviewed; 498 AA.
AC Q5WHY3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Argininosuccinate lyase 1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL 1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase 1 {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH1 {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=ABC1487;
OS Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=66692;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSM-K16;
RA Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA Kawai S., Ito S., Horikoshi K.;
RT "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT K16.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; AP006627; BAD64022.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5WHY3; -.
DR SMR; Q5WHY3; -.
DR STRING; 66692.ABC1487; -.
DR EnsemblBacteria; BAD64022; BAD64022; ABC1487.
DR KEGG; bcl:ABC1487; -.
DR eggNOG; COG0165; Bacteria.
DR HOGENOM; CLU_027272_2_3_9; -.
DR OMA; YTNGVAA; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000001168; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW Reference proteome.
FT CHAIN 1..498
FT /note="Argininosuccinate lyase 1"
FT /id="PRO_0000240712"
SQ SEQUENCE 498 AA; 55866 MW; 327B7C4574427E31 CRC64;
MVGRLKESPS QEMIDLLFKP SIRSDLKHHY SYLLKINSVH LFMLKSEGII SDEAASKIHS
VLTHLQVTGK EALSINPALE DLYFNVEAYI IEQTGPEIGG QMHTGRSRND ILATVTRMRI
REEMLEIYEL VCTLRRTLID LATEHTSTLM TGYTHLQPAE PITFAHYLSA LLHGFERDFT
RLYNCYAHIN KSPLGSCALA STTFSINRKF TMELLGFADL LENSLDGIAS RDYALEALSA
LSIFSNSLSR FAQDLYTWCS YEFGYLEVGH SVAVISSIMP QKKNPVTLEH IKAKAGHIQG
ALVSSLSVLK NTLYSHSRDT SMESMKYTWE AINETKAAIR LMIKTLQTLT VHKDNMAATT
RQNFSTVTEL ANALVRHYHF SFRTAHHIVA EIVNETLNQG LGSDKIEAST VERAIKQVTA
KTVSVTKEFV EQALDPERNI SLRTVRGGSA PVEVARQLQQ LEQTLASDHQ KISDLKQALQ
SADQLYKHYA AELERGAQ
