ARLY1_CHICK
ID ARLY1_CHICK Reviewed; 466 AA.
AC P02521; Q90814;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Delta-1 crystallin;
DE AltName: Full=Delta crystallin I;
GN Name=ASL1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3839507; DOI=10.1016/s0021-9258(17)39335-3;
RA Nickerson J.M., Wawrousek E.F., Hawkins J.W., Wakil A.S., Wistow G.J.,
RA Thomas G., Norman B.L., Piatigorsky J.;
RT "The complete sequence of the chicken delta 1 crystallin gene and its 5'
RT flanking region.";
RL J. Biol. Chem. 260:9100-9105(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2987831; DOI=10.1093/nar/13.5.1593;
RA Ohno M., Sakamoto H., Yasuda K., Okada T.S., Shimura Y.;
RT "Nucleotide sequence of a chicken delta-crystallin gene.";
RL Nucleic Acids Res. 13:1593-1606(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-447, TISSUE SPECIFICITY, AND BLOCKAGE OF
RP N-TERMINUS.
RC TISSUE=Lens;
RX PubMed=6547670; DOI=10.1002/j.1460-2075.1984.tb01983.x;
RA Yasuda K., Nakajima N., Isobe T., Okada T.S., Shimura Y.;
RT "The nucleotide sequence of a complete chicken delta-crystallin cDNA.";
RL EMBO J. 3:1397-1402(1984).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-447, AND TISSUE SPECIFICITY.
RC TISSUE=Lens;
RX PubMed=6585817; DOI=10.1073/pnas.81.9.2611;
RA Nickerson J.M., Piatigorsky J.;
RT "Sequence of a complete chicken delta-crystallin cDNA.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:2611-2615(1984).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-4.
RC STRAIN=White leghorn;
RX PubMed=4018032; DOI=10.1002/j.1460-2075.1985.tb03649.x;
RA Borras T., Nickerson J.M., Chepelinsky A.B., Piatigorsky J.;
RT "Structural and functional evidence for differential promoter activity of
RT the two linked delta-crystallin genes in the chicken.";
RL EMBO J. 4:445-452(1985).
CC -!- FUNCTION: Delta crystallin, the principal crystallin in embryonic lens,
CC is found only in birds and reptiles.
CC -!- SUBUNIT: Homotetramer.
CC -!- TISSUE SPECIFICITY: Eye lens. {ECO:0000269|PubMed:6547670,
CC ECO:0000269|PubMed:6585817}.
CC -!- PTM: The N-terminus is blocked.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000305}.
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DR EMBL; M10806; AAA48726.1; -; Genomic_DNA.
DR EMBL; X02222; CAA26144.1; -; Genomic_DNA.
DR EMBL; X00626; CAA25260.1; -; mRNA.
DR EMBL; L29393; AAL58666.1; -; Genomic_DNA.
DR EMBL; J00843; AAA48728.1; -; mRNA.
DR EMBL; X02187; CAA26128.1; -; Genomic_DNA.
DR PIR; A25712; CYCHD.
DR RefSeq; NP_990832.2; NM_205501.2.
DR AlphaFoldDB; P02521; -.
DR SMR; P02521; -.
DR STRING; 9031.ENSGALP00000039143; -.
DR PaxDb; P02521; -.
DR PRIDE; P02521; -.
DR Ensembl; ENSGALT00000083127; ENSGALP00000062684; ENSGALG00000002558.
DR GeneID; 396498; -.
DR KEGG; gga:396498; -.
DR CTD; 396498; -.
DR VEuPathDB; HostDB:geneid_396498; -.
DR eggNOG; KOG1316; Eukaryota.
DR GeneTree; ENSGT00950000183122; -.
DR HOGENOM; CLU_027272_2_1_1; -.
DR InParanoid; P02521; -.
DR PhylomeDB; P02521; -.
DR TreeFam; TF300656; -.
DR Reactome; R-GGA-187630; Arginine metabolism.
DR Reactome; R-GGA-70635; Urea cycle.
DR PRO; PR:P02521; -.
DR Proteomes; UP000000539; Chromosome 19.
DR Bgee; ENSGALG00000002558; Expressed in liver and 11 other tissues.
DR ExpressionAtlas; P02521; baseline and differential.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004056; F:argininosuccinate lyase activity; TAS:Reactome.
DR GO; GO:0005212; F:structural constituent of eye lens; TAS:UniProtKB.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR GO; GO:0006525; P:arginine metabolic process; TAS:Reactome.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
PE 1: Evidence at protein level;
KW Eye lens protein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..466
FT /note="Delta-1 crystallin"
FT /id="PRO_0000137719"
FT MOD_RES 2
FT /note="Blocked amino end (Ala)"
FT /evidence="ECO:0000269|PubMed:6547670"
FT VARIANT 345
FT /note="V -> A"
FT CONFLICT 118
FT /note="V -> L (in Ref. 3; CAA25260)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="I -> T (in Ref. 3; CAA25260)"
FT /evidence="ECO:0000305"
FT CONFLICT 274
FT /note="S -> F (in Ref. 3; CAA25260)"
FT /evidence="ECO:0000305"
FT CONFLICT 348
FT /note="G -> E (in Ref. 3; CAA25260)"
FT /evidence="ECO:0000305"
FT CONFLICT 443
FT /note="T -> H (in Ref. 4; AAA48728)"
FT /evidence="ECO:0000305"
FT CONFLICT 446..447
FT /note="SS -> AA (in Ref. 3; CAA25260 and 4; AAA48728)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 466 AA; 50796 MW; 712A904F8CC430C5 CRC64;
MATEGDKLLG GRFVGSTDPI MEILSSSIST EQRLTEVDIQ ASMAYAKALE KASILTKTEL
EKILSGLEKI SEESSKGVLV MTQSDEDIQT AIERRLKELI GDIAGKLQTG RSRNEQVVTD
LKLLLKSSIS VISTHLLQLI KTLVERAAIE IDIIMPGYTH LQKALPIRWS QFLLSHAVAL
TRDSERLGEV KKRITVLPLG SGALAGNPLE IDRELLRSEL DMTSITLNSI DAISERDFVV
ELISVATLLM IHLSKLAEDL IIFSTTEFGF VTLSDAYSTG SSLLPQKKNP DSLELIRSKA
GRVFGRLAAI LMVLKGIPST FSKDLQEDKE AVLDVVDTLT AVLQVATGVI STLQVNKENM
EKALTPELLS TDLALYLVRK GMPIRQAQTA SGKAVHLAET KGITINNLTL EDLKSISPLF
ASDVSQVFSV VNSVEQYTAV GGTAKSSVTA QIEQLRELLK KQKEQA
