ID   ARLY1_PSEPF             Reviewed;         475 AA.
AC   Q3KCB2;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Argininosuccinate lyase 1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL 1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase 1 {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH1 {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=Pfl01_2852;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1;
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; CP000094; ABA74593.1; -; Genomic_DNA.
DR   RefSeq; WP_011334264.1; NC_007492.2.
DR   AlphaFoldDB; Q3KCB2; -.
DR   SMR; Q3KCB2; -.
DR   STRING; 205922.Pfl01_2852; -.
DR   PRIDE; Q3KCB2; -.
DR   EnsemblBacteria; ABA74593; ABA74593; Pfl01_2852.
DR   KEGG; pfo:Pfl01_2852; -.
DR   eggNOG; COG0165; Bacteria.
DR   HOGENOM; CLU_027272_2_2_6; -.
DR   OMA; RQFRWVE; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT   CHAIN           1..475
FT                   /note="Argininosuccinate lyase 1"
FT                   /id="PRO_0000240752"
SQ   SEQUENCE   475 AA;  51912 MW;  076B831E8988AA60 CRC64;
     MSQTTDRLWG ARFKSGPSAA LAALSRCPER YFRLTPYDLA GSKAHAGELQ RAGLLDEQET
     RTMIEALDGI GADFAAGRIA PTLDDEDVHT FIERLLTERL GALGGKLRAG RSRNDQTAND
     LRLFLRDHVR TLAVEVLALQ TALVDQAEQH VESICPGFTH LQQAQPIVFA HHLLAHAQSM
     LRDVQRLMDW DARTSLSPLG AAAMAGSAIA RQPQQSAKEM GYAGVCENSI DAVASRDHVA
     EFLFIASMLG INISRLAEEF CLWSSRQFRW VDLDDAYATG SSIMPQKKNP DIAELARGKA
     GRLIGNLTGL LSTLKSLPLS YNRDLSEDKN GVLDSVDTLL LVLPAMAGMV ATMTVNVEEL
     RRQAPLGFTL ATEVADWLAV RGVPFKEAHE ITGALVQACE KHDLELWEAS PALLAEIDPR
     LTADVRDSLT LEAAIAARSG WGGTAPQQVR EQIGRLKTAL AAQQQWTENY QGFRL