METL2_ARATH
ID METL2_ARATH Reviewed; 414 AA.
AC Q8LFA9; Q8GYB7; Q9LN64;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Methyltransferase-like protein 2;
DE EC=2.1.1.-;
GN OrderedLocusNames=At1g19340; ORFNames=F18O14.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-414.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000255|PROSITE-
CC ProRule:PRU00489}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79421.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC42388.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC025808; AAF79421.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29833.1; -; Genomic_DNA.
DR EMBL; AY084952; AAM61513.1; -; mRNA.
DR EMBL; AK117739; BAC42388.1; ALT_INIT; mRNA.
DR RefSeq; NP_564080.1; NM_101791.3.
DR PDB; 7CV6; X-ray; 3.01 A; B=1-414.
DR PDB; 7CV7; X-ray; 2.30 A; A/B=1-414.
DR PDB; 7CV8; X-ray; 2.37 A; A=1-414.
DR PDB; 7CV9; X-ray; 2.46 A; A/C=1-414.
DR PDB; 7CVA; X-ray; 2.50 A; A/B=1-414.
DR PDB; 7DPE; X-ray; 2.75 A; A=1-414.
DR PDBsum; 7CV6; -.
DR PDBsum; 7CV7; -.
DR PDBsum; 7CV8; -.
DR PDBsum; 7CV9; -.
DR PDBsum; 7CVA; -.
DR PDBsum; 7DPE; -.
DR AlphaFoldDB; Q8LFA9; -.
DR SMR; Q8LFA9; -.
DR STRING; 3702.AT1G19340.1; -.
DR PaxDb; Q8LFA9; -.
DR PRIDE; Q8LFA9; -.
DR ProteomicsDB; 250618; -.
DR DNASU; 838516; -.
DR EnsemblPlants; AT1G19340.1; AT1G19340.1; AT1G19340.
DR GeneID; 838516; -.
DR Gramene; AT1G19340.1; AT1G19340.1; AT1G19340.
DR KEGG; ath:AT1G19340; -.
DR Araport; AT1G19340; -.
DR TAIR; locus:2016462; AT1G19340.
DR eggNOG; KOG2356; Eukaryota.
DR HOGENOM; CLU_027091_3_1_1; -.
DR InParanoid; Q8LFA9; -.
DR OMA; EPLRFQD; -.
DR OrthoDB; 1496188at2759; -.
DR PRO; PR:Q8LFA9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8LFA9; baseline and differential.
DR Genevisible; Q8LFA9; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008168; F:methyltransferase activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043414; P:macromolecule methylation; IEA:UniProt.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
DR PROSITE; PS51143; MT_A70; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Methyltransferase; Reference proteome; Transferase.
FT CHAIN 1..414
FT /note="Methyltransferase-like protein 2"
FT /id="PRO_0000260074"
FT REGION 56..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 59
FT /note="H -> Q (in Ref. 3; AAM61513 and 4; BAC42388)"
FT /evidence="ECO:0000305"
FT HELIX 3..13
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 14..17
FT /evidence="ECO:0007829|PDB:7CV7"
FT TURN 19..22
FT /evidence="ECO:0007829|PDB:7DPE"
FT STRAND 23..26
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 28..33
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 37..40
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 43..46
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 48..51
FT /evidence="ECO:0007829|PDB:7CV8"
FT TURN 82..84
FT /evidence="ECO:0007829|PDB:7CV9"
FT HELIX 87..106
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 109..117
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 131..133
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 140..144
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 149..151
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 153..157
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 172..176
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 178..184
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 186..188
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 190..194
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 197..201
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 205..209
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 212..218
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 222..224
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 227..232
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 245..247
FT /evidence="ECO:0007829|PDB:7CV9"
FT HELIX 252..257
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 260..263
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 269..275
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 279..287
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 289..293
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 296..306
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 310..314
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 319..321
FT /evidence="ECO:0007829|PDB:7CV9"
FT STRAND 323..332
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 352..356
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 360..362
FT /evidence="ECO:0007829|PDB:7CV9"
FT HELIX 368..371
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 372..374
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 378..380
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 383..386
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 395..400
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 404..406
FT /evidence="ECO:0007829|PDB:7CV7"
FT HELIX 408..410
FT /evidence="ECO:0007829|PDB:7CV7"
FT STRAND 411..413
FT /evidence="ECO:0007829|PDB:7CV8"
SQ SEQUENCE 414 AA; 47893 MW; 6DC70F4347BFDDA8 CRC64;
MAKTDKLAQF LDSGIYESDE FNWFFLDTVR ITNRSYTRFK VSPSAYYSRF FNSKQLNQHS
SESNPKKRKR KQKNSSFHLP SVGEQASNLR HQEARLFLSK AHESFLKEIE LLSLTKGLSD
DNDDDDSSLL NKCCDDEVSF IELGGVWQAP FYEITLSFNL HCDNEGESCN EQRVFQVFNN
LVVNEIGEEV EAEFSNRRYI MPRNSCFYMS DLHHIRNLVP AKSEEGYNLI VIDPPWENAS
AHQKSKYPTL PNQYFLSLPI KQLAHAEGAL VALWVTNREK LLSFVEKELF PAWGIKYVAT
MYWLKVKPDG TLICDLDLVH HKPYEYLLLG YHFTELAGSE KRSDFKLLDK NQIIMSIPGD
FSRKPPIGDI LLKHTPGSQP ARCLELFARE MAAGWTSWGN EPLHFQDSRY FLKV
