ARLY_ACTP7
ID ARLY_ACTP7 Reviewed; 458 AA.
AC B3GY67;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=APP7_1238;
OS Actinobacillus pleuropneumoniae serotype 7 (strain AP76).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=537457;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP76;
RA Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N.,
RA Tegetmeyer H., Singh M., Gerlach G.F.;
RT "Genome and proteome analysis of A. pleuropneumoniae serotype 7.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; CP001091; ACE61890.1; -; Genomic_DNA.
DR RefSeq; WP_005617656.1; NC_010939.1.
DR AlphaFoldDB; B3GY67; -.
DR SMR; B3GY67; -.
DR EnsemblBacteria; ACE61890; ACE61890; APP7_1238.
DR KEGG; apa:APP7_1238; -.
DR HOGENOM; CLU_027272_2_3_6; -.
DR OMA; KKNPDVF; -.
DR BioCyc; APLE537457:APP7_RS06320-MON; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000001226; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT CHAIN 1..458
FT /note="Argininosuccinate lyase"
FT /id="PRO_1000089062"
SQ SEQUENCE 458 AA; 51048 MW; FDF8C99AEDB81BD5 CRC64;
MALWGGRFKQ EADAKFKFFN DSLRFDYRLA LQDIDGSIGW AKAITSVGIL TEQEHQQLVV
ALKELRAEIE PNIAIILRDD AEDIHSWVES KLIEKVGDLG KKLHTGRSRN DQVAVDMKMW
CKVQAVVLQE RIRNLQHKLV ETAEANQNAV MPGYTHLQRA QPITFAHWCM AYYEMLERDF
SRLSDAYKRM HTCPLGSGAL AGTAYSIDRD ALAQDLGFSI GTRNSLDSVS DRDHVLELLS
TASISMVHLS RFAEDLIFFN SGESAFLELS DRVTSGSSLM PQKKNPDACE LIRGKSGRVF
GALSGLLTTL KGLPLAYNKD MQEDKEGIFD AMETWQACLE IGALVLEDIN VNVERTREAA
QQGYSNATEL ADYLVAKGIP FREAHHIVGE AVVYAISKRE PLEALSVAEF KQFHPVIDED
VYPILSLESC LEKRSAKGGV NPERVREAIE AAKVNLGA
