ID   METQ_HAEIN              Reviewed;         273 AA.
AC   P31728;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Probable D-methionine-binding lipoprotein MetQ;
DE   AltName: Full=28 kDa outer membrane protein;
DE   Flags: Precursor;
GN   Name=metQ; Synonyms=hlpA; OrderedLocusNames=HI_0620;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Serotype B;
RX   PubMed=1987077; DOI=10.1128/iai.59.2.600-608.1991;
RA   Chanyangam M., Smith A.L., Moseley S.L., Kuehn M., Jenny P.;
RT   "Contribution of a 28-kilodalton membrane protein to the virulence of
RT   Haemophilus influenzae.";
RL   Infect. Immun. 59:600-608(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: This protein is a component of a D-methionine permease, a
CC       binding protein-dependent, ATP-driven transport system. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NlpA lipoprotein family. {ECO:0000305}.
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DR   EMBL; M59804; AAA24939.1; -; Genomic_DNA.
DR   EMBL; L42023; AAC22279.1; -; Genomic_DNA.
DR   PIR; B64082; B64082.
DR   RefSeq; NP_438778.1; NC_000907.1.
DR   RefSeq; WP_005694548.1; NC_000907.1.
DR   AlphaFoldDB; P31728; -.
DR   SMR; P31728; -.
DR   STRING; 71421.HI_0620; -.
DR   EnsemblBacteria; AAC22279; AAC22279; HI_0620.
DR   KEGG; hin:HI_0620; -.
DR   PATRIC; fig|71421.8.peg.644; -.
DR   eggNOG; COG1464; Bacteria.
DR   HOGENOM; CLU_067080_3_0_6; -.
DR   OMA; YQDDAES; -.
DR   PhylomeDB; P31728; -.
DR   BioCyc; HINF71421:G1GJ1-641-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004872; Lipoprotein_NlpA.
DR   PANTHER; PTHR30429; PTHR30429; 1.
DR   Pfam; PF03180; Lipoprotein_9; 1.
DR   PIRSF; PIRSF002854; MetQ; 1.
DR   TIGRFAMs; TIGR00363; TIGR00363; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Cell outer membrane; Lipoprotein; Membrane;
KW   Palmitate; Reference proteome; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000305"
FT   CHAIN           21..273
FT                   /note="Probable D-methionine-binding lipoprotein MetQ"
FT                   /id="PRO_0000019745"
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        249
FT                   /note="I -> V (in Ref. 1; AAA24939)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   273 AA;  29828 MW;  429838A8AC7DD7D7 CRC64;
     MKLKQLFAIT AIASALVLTG CKEDKKPEAA AAPLKIKVGV MSGPEHQVAE IAAKVAKEKY
     GLDVQFVEFN DYALPNEAVS KGDLDANAMQ HKPYLDEDAK AKNLNNLVIV GNTFVYPLAG
     YSKKIKNVNE LQDGAKVVVP NDPTNRGRAL ILLEKQGLIK LKDANNLLST VLDIVENPKK
     LNITEVDTSV AARALDDVDL AVVNNTYAGQ VGLNAQDDGV FVEDKDSPYV NIIVSRTDNK
     DSKAVQDFIK SYQTEEVYQE AQKHFKDGVV KGW