ID   METRL_DANRE             Reviewed;         286 AA.
AC   Q7ZV46;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Meteorin-like protein;
DE   Flags: Precursor;
GN   Name=metrnl; ORFNames=zgc:56225;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hormone induced following exercise or cold exposure that
CC       promotes energy expenditure. Induced either in the skeletal muscle
CC       after exercise or in adipose tissue following cold exposure and is
CC       present in the circulation. Able to stimulate energy expenditure
CC       associated with the browning of the white fat depots and improves
CC       glucose tolerance (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the meteorin family. {ECO:0000305}.
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DR   EMBL; BC046006; AAH46006.1; -; mRNA.
DR   RefSeq; NP_998150.1; NM_212985.1.
DR   AlphaFoldDB; Q7ZV46; -.
DR   STRING; 7955.ENSDARP00000068919; -.
DR   PaxDb; Q7ZV46; -.
DR   GeneID; 406258; -.
DR   KEGG; dre:406258; -.
DR   CTD; 406258; -.
DR   ZFIN; ZDB-GENE-040426-1917; metrnla.
DR   eggNOG; ENOG502QUQB; Eukaryota.
DR   InParanoid; Q7ZV46; -.
DR   OrthoDB; 1364884at2759; -.
DR   PhylomeDB; Q7ZV46; -.
DR   PRO; PR:Q7ZV46; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR   GO; GO:0050873; P:brown fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0097009; P:energy homeostasis; ISS:UniProtKB.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0090336; P:positive regulation of brown fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0009409; P:response to cold; ISS:UniProtKB.
DR   GO; GO:0014850; P:response to muscle activity; ISS:UniProtKB.
DR   Gene3D; 2.40.50.120; -; 1.
DR   InterPro; IPR039224; Meteorin-like.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR28593:SF1; PTHR28593:SF1; 1.
DR   SUPFAM; SSF50242; SSF50242; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..286
FT                   /note="Meteorin-like protein"
FT                   /id="PRO_0000289107"
FT   DISULFID        28..51
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        84..120
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        165..235
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        168..259
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        178..281
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   286 AA;  31709 MW;  A4B7B1BCF36190DA CRC64;
     MLSPFLAYLL SVVLLCRIAR SQYSSDQCSW RGSGLTHEGH TRGVEQVYLR CAQGFLEWLY
     PTGAIIVNLR PNTLSPAASL LSVCIKPSKE SSGTHIYLDR LGKLRLLLSE GDQAEGKVHC
     FNIQDGALFI EAVPQRDISR KITAFQYELV NHRPGADPQS LSAPCQPCTD AEVLLAVCTS
     DFVARGRILG VSEEDEQTSV TVSLSHLYRQ KTQVFVSGGG RAKRWTGFVK MSRQCGVKPG
     DGEFLFTGTV RFGEAWLSCA PRYKDFLRVY QDARQQGTNP CHLETD