ID   METRL_XENLA             Reviewed;         286 AA.
AC   A1L2K1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Meteorin-like protein;
DE   Flags: Precursor;
GN   Name=metrnl;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hormone induced following exercise or cold exposure that
CC       promotes energy expenditure. Induced either in the skeletal muscle
CC       after exercise or in adipose tissue following cold exposure and is
CC       present in the circulation. Able to stimulate energy expenditure
CC       associated with the browning of the white fat depots and improves
CC       glucose tolerance (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the meteorin family. {ECO:0000305}.
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DR   EMBL; BC129567; AAI29568.1; -; mRNA.
DR   RefSeq; NP_001091122.1; NM_001097653.1.
DR   AlphaFoldDB; A1L2K1; -.
DR   GeneID; 100036871; -.
DR   KEGG; xla:100036871; -.
DR   CTD; 100036871; -.
DR   Xenbase; XB-GENE-6078852; metrnl.L.
DR   OrthoDB; 1364884at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 100036871; Expressed in heart and 19 other tissues.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR   GO; GO:0050873; P:brown fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0097009; P:energy homeostasis; ISS:UniProtKB.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0090336; P:positive regulation of brown fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0009409; P:response to cold; ISS:UniProtKB.
DR   GO; GO:0014850; P:response to muscle activity; ISS:UniProtKB.
DR   InterPro; IPR039224; Meteorin-like.
DR   PANTHER; PTHR28593:SF1; PTHR28593:SF1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..286
FT                   /note="Meteorin-like protein"
FT                   /id="PRO_0000289108"
FT   CARBOHYD        203
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..51
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        84..120
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        165..235
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        168..259
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        178..281
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   286 AA;  32144 MW;  0411F61E8A6983F4 CRC64;
     MLRRGLLSFF MVILIDRGTS QLYSSDMCNW KGSGLTHEGH TKDVEQVYLR CSEGSVEWLY
     PTGAMVINLR PNTLTSAYKH LTVCIKPFKD SKGANIYSEK TGELKLVVPD GENNPHKVYC
     FGLDRGGLYI EATPQQDISR KITGFQYELI SQRTLSDLHT VSDPCRPCSD TEVLLAVCIS
     DFVVKGTISA VTNDEELQES LINVTVDKLY RQKSKIFLPK DNGGWEGMIR TPLECGVKTG
     MGSFLFTGRM HFGEPRLGCT PRYKDFKRIY LEAKKQGLNP CEISTD