METRN_HUMAN
ID METRN_HUMAN Reviewed; 293 AA.
AC Q9UJH8; Q9UJH9;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Meteorin;
DE Flags: Precursor;
GN Name=METRN; Synonyms=C16orf23; ORFNames=RJD6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15085178; DOI=10.1038/sj.emboj.7600202;
RA Nishino J., Yamashita K., Hashiguchi H., Fujii H., Shimazaki T., Hamada H.;
RT "Meteorin: a secreted protein that regulates glial cell differentiation and
RT promotes axonal extension.";
RL EMBO J. 23:1998-2008(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C.,
RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of
RT the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in both glial cell differentiation and axonal
CC network formation during neurogenesis. Promotes astrocyte
CC differentiation and transforms cerebellar astrocytes into radial glia.
CC Also induces axonal extension in small and intermediate neurons of
CC sensory ganglia by activating nearby satellite glia (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the meteorin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE006464; AAK61247.1; -; Genomic_DNA.
DR EMBL; Z97653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000662; AAH00662.1; -; mRNA.
DR CCDS; CCDS10422.1; -.
DR RefSeq; NP_076947.1; NM_024042.3.
DR AlphaFoldDB; Q9UJH8; -.
DR BioGRID; 122477; 81.
DR IntAct; Q9UJH8; 4.
DR MINT; Q9UJH8; -.
DR STRING; 9606.ENSP00000455068; -.
DR iPTMnet; Q9UJH8; -.
DR PhosphoSitePlus; Q9UJH8; -.
DR BioMuta; METRN; -.
DR DMDM; 50401202; -.
DR MassIVE; Q9UJH8; -.
DR PaxDb; Q9UJH8; -.
DR PeptideAtlas; Q9UJH8; -.
DR PRIDE; Q9UJH8; -.
DR ProteomicsDB; 84625; -.
DR Antibodypedia; 22849; 108 antibodies from 16 providers.
DR DNASU; 79006; -.
DR Ensembl; ENST00000568223.7; ENSP00000455068.1; ENSG00000103260.9.
DR GeneID; 79006; -.
DR KEGG; hsa:79006; -.
DR MANE-Select; ENST00000568223.7; ENSP00000455068.1; NM_024042.4; NP_076947.1.
DR UCSC; uc010bra.4; human.
DR CTD; 79006; -.
DR DisGeNET; 79006; -.
DR GeneCards; METRN; -.
DR HGNC; HGNC:14151; METRN.
DR HPA; ENSG00000103260; Tissue enhanced (brain, choroid plexus).
DR MIM; 610998; gene.
DR neXtProt; NX_Q9UJH8; -.
DR OpenTargets; ENSG00000103260; -.
DR PharmGKB; PA25537; -.
DR VEuPathDB; HostDB:ENSG00000103260; -.
DR eggNOG; ENOG502QUQB; Eukaryota.
DR GeneTree; ENSGT00390000001390; -.
DR HOGENOM; CLU_069970_0_0_1; -.
DR InParanoid; Q9UJH8; -.
DR OMA; EACRPCN; -.
DR OrthoDB; 1364884at2759; -.
DR PhylomeDB; Q9UJH8; -.
DR TreeFam; TF330918; -.
DR PathwayCommons; Q9UJH8; -.
DR SignaLink; Q9UJH8; -.
DR BioGRID-ORCS; 79006; 11 hits in 1072 CRISPR screens.
DR ChiTaRS; METRN; human.
DR GenomeRNAi; 79006; -.
DR Pharos; Q9UJH8; Tbio.
DR PRO; PR:Q9UJH8; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9UJH8; protein.
DR Bgee; ENSG00000103260; Expressed in C1 segment of cervical spinal cord and 177 other tissues.
DR ExpressionAtlas; Q9UJH8; baseline and differential.
DR Genevisible; Q9UJH8; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0010001; P:glial cell differentiation; IBA:GO_Central.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IBA:GO_Central.
DR GO; GO:0060019; P:radial glial cell differentiation; IEA:Ensembl.
DR InterPro; IPR039229; Meteorin.
DR PANTHER; PTHR28593:SF2; PTHR28593:SF2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Neurogenesis;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..293
FT /note="Meteorin"
FT /id="PRO_0000021680"
FT DISULFID 30..51
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 82..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 171..242
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 174..266
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 184..288
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 293 AA; 31207 MW; 45B9136BF9153F28 CRC64;
MGFPAAALLC ALCCGLLAPA ARAGYSEERC SWRGSGLTQE PGSVGQLALA CAEGAVEWLY
PAGALRLTLG GPDPRARPGI ACLRPVRPFA GAQVFAERAG GALELLLAEG PGPAGGRCVR
WGPRERRALF LQATPHQDIS RRVAAFRFEL REDGRPELPP QAHGLGVDGA CRPCSDAELL
LAACTSDFVI HGIIHGVTHD VELQESVITV VAARVLRQTP PLFQAGRSGD QGLTSIRTPL
RCGVHPGPGT FLFMGWSRFG EARLGCAPRF QEFRRAYEAA RAAHLHPCEV ALH
