ID   METRN_RAT               Reviewed;         291 AA.
AC   Q5Q0T9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Meteorin;
DE   AltName: Full=Hypoxia/reoxygenation regulatory factor;
DE   Flags: Precursor;
GN   Name=Metrn; Synonyms=Hyrac;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Park J.A., Song H.S., Kim K.-W.;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in both glial cell differentiation and axonal
CC       network formation during neurogenesis. Promotes astrocyte
CC       differentiation and transforms cerebellar astrocytes into radial glia.
CC       Also induces axonal extension in small and intermediate neurons of
CC       sensory ganglia by activating nearby satellite glia (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the meteorin family. {ECO:0000305}.
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DR   EMBL; AY800384; AAV74418.1; -; mRNA.
DR   RefSeq; NP_001009962.1; NM_001009962.1.
DR   AlphaFoldDB; Q5Q0T9; -.
DR   STRING; 10116.ENSRNOP00000026676; -.
DR   PaxDb; Q5Q0T9; -.
DR   PRIDE; Q5Q0T9; -.
DR   Ensembl; ENSRNOT00000026676; ENSRNOP00000026676; ENSRNOG00000019692.
DR   GeneID; 287151; -.
DR   KEGG; rno:287151; -.
DR   UCSC; RGD:1306222; rat.
DR   CTD; 79006; -.
DR   RGD; 1306222; Metrn.
DR   eggNOG; ENOG502QUQB; Eukaryota.
DR   GeneTree; ENSGT00390000001390; -.
DR   HOGENOM; CLU_069970_0_0_1; -.
DR   InParanoid; Q5Q0T9; -.
DR   OMA; EACRPCN; -.
DR   OrthoDB; 1364884at2759; -.
DR   PhylomeDB; Q5Q0T9; -.
DR   TreeFam; TF330918; -.
DR   PRO; PR:Q5Q0T9; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000019692; Expressed in frontal cortex and 19 other tissues.
DR   Genevisible; Q5Q0T9; RN.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR   GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR   GO; GO:0010001; P:glial cell differentiation; ISO:RGD.
DR   GO; GO:0050772; P:positive regulation of axonogenesis; ISO:RGD.
DR   GO; GO:0060019; P:radial glial cell differentiation; IEA:Ensembl.
DR   InterPro; IPR039229; Meteorin.
DR   PANTHER; PTHR28593:SF2; PTHR28593:SF2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Disulfide bond; Neurogenesis;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..291
FT                   /note="Meteorin"
FT                   /id="PRO_0000289103"
FT   DISULFID        28..49
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        80..116
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        169..240
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        172..264
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        182..286
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   291 AA;  31353 MW;  E50F49FFB5824A11 CRC64;
     MLVAALLCAL CCGLLAASAR AGYSEDRCSW RGSGLTQEPG SVGQLTLDCT EGAIEWLYPA
     GALRLTLGGS DPGTRPSIVC LRPTRPFAGA QVFAERMAGN LELLLAEGQG LAGGRCMRWG
     PRERRALFLQ ATPHRDISRR VAAFQFELHE DQRAEMSPQA QGFGVDGACR PCSDAELLLT
     ACTSDFVIHG TIHGVVHDME LQESVITVVA TRVIRQTLPL FQEGSSEGRG QASVRTLLRC
     GVRPGPGSFL FMGWSRFGEA WLGCAPRFQE FSRVYSAALA AHLNPCEVAL D