ID   METR_BUCAP              Reviewed;         312 AA.
AC   Q8KA72;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=HTH-type transcriptional regulator MetR;
GN   Name=metR; OrderedLocusNames=BUsg_030;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: Control of the last step in methionine biosynthesis; MetR is
CC       a positive activator of the metA, metE and metH genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE013218; AAM67601.1; -; Genomic_DNA.
DR   RefSeq; WP_011053567.1; NC_004061.1.
DR   AlphaFoldDB; Q8KA72; -.
DR   SMR; Q8KA72; -.
DR   STRING; 198804.BUsg_030; -.
DR   EnsemblBacteria; AAM67601; AAM67601; BUsg_030.
DR   KEGG; bas:BUsg_030; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_0_6; -.
DR   OMA; YPVPDDM; -.
DR   OrthoDB; 750230at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd08441; PBP2_MetR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037406; MetR_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Cytoplasm; DNA-binding;
KW   Methionine biosynthesis; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..312
FT                   /note="HTH-type transcriptional regulator MetR"
FT                   /id="PRO_0000105678"
FT   DOMAIN          1..59
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  36186 MW;  9745DD65DAF8BC34 CRC64;
     MIEIKHLRTL QALKNNGSLS AAAIQLHQTQ SAISHQFNEL EKKLGFKLFI RKSNPIKFTA
     QGEILLQLSK EILPKIHKAI QNCKKTHQMI IKLAIECHSC IQWLTPALKI FQKKWPRVEI
     DFYSDMIFSP QPSLQQGKLD IVLTSEVLPR SNLFYFPIFD FEVRLVLSPN HPLAQKKHNI
     LPEDLISEIL MIYPVKRDKL DIWKFFLQPA GIIPIFKNVN NTLLLIQMVA AKMGITALPH
     WVVDTFEKQG LVVTKKLGDG IWKRLYAAIR DGDQKELIIK NFIYAIRLHV CTHLKFIRDT
     QKPHFFKNVK NI