ID   METR_HAEIN              Reviewed;         309 AA.
AC   P45349;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=HTH-type transcriptional regulator MetR;
GN   Name=metR; OrderedLocusNames=HI_1739;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Control of the last step in methionine biosynthesis; MetR is
CC       a positive activator of the metA, metE and metH genes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC23383.1; -; Genomic_DNA.
DR   PIR; D64139; D64139.
DR   RefSeq; NP_439881.1; NC_000907.1.
DR   RefSeq; WP_005694223.1; NC_000907.1.
DR   AlphaFoldDB; P45349; -.
DR   SMR; P45349; -.
DR   STRING; 71421.HI_1739; -.
DR   DNASU; 950886; -.
DR   EnsemblBacteria; AAC23383; AAC23383; HI_1739.
DR   KEGG; hin:HI_1739; -.
DR   PATRIC; fig|71421.8.peg.1820; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_0_6; -.
DR   OMA; YPVPDDM; -.
DR   PhylomeDB; P45349; -.
DR   BioCyc; HINF71421:G1GJ1-1755-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd08441; PBP2_MetR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037406; MetR_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Amino-acid biosynthesis; Cytoplasm; DNA-binding;
KW   Methionine biosynthesis; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..309
FT                   /note="HTH-type transcriptional regulator MetR"
FT                   /id="PRO_0000105679"
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   309 AA;  35345 MW;  A0C2F0277DE8B274 CRC64;
     MKPTFLEFRH LKTLLALKET GSVSLAAKRV YLTQSALSHQ IKLIEEQFGL PLFERKSNPL
     RFTSAGERLI RLANEVMPKV IDAERDLARV KHGDAGQLRI AVECHTCFDW LMPAMDEFRQ
     HWGLVELDIV SGFHTDPVGL LLSHRADWAI VSEIEHNDDV IFKPLFSYEM VGICSKNHSL
     AEKDIWEAED FIDETWVTYP VPDDMLDLWR KVLKSKGINP TRRTTELTIA MIQLVASRRG
     IATIPYWAAL PYLEKGYVVA RKVTKEGLYS NLYAAIRKED ESLSYLEDFY QTVKSQSFST
     LPGLSVLNL